Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
OMG!
111% now stop playing!
Donated 600 pennies to the shop.
Unlocked a new co-player baby.
Built him out of meat cubes.
Unlocked Challenge #11.
Isaac now holds the D6!
You became Lord of the Flies.
Donated 200 pennies to the shop.
New boss in the womb!
Unlocked Challenge #19.
Unlocked a new boss!
You are the best!!
Beat Chest or Dark Room without taking damage.
They are waiting.
New boss in the caves!
Beat depths without taking damage.
New boss in the basement!
Unlocked Challenge #4.
Unlocked Challenge #7.
Your future's past waits.
New boss in the depths!
Unlocked Challenge #9.
Beat womb without taking damage.
Unlocked Challenge #8.
Donated 100 pennies to the shop.
The game just got harder!
Unlocked another miniboss!
Beat caves without taking damage.
Beat basement without taking damage.
Unlocked Challenge #6.
Destroy 100 rocks.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Donated 20 pennies to the shop.
Unlocked Challenge #5.
Unlocked Challenge #10.
Nerd x 1000000
Unlocked...
Unlocked a new starting item.
Unlocked a new item
Unlocked a secret.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #24.
Greed just got harder!
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked a new challenge.
Unlocked the power of RERUN.
Unlocked a new area.
They will charge you up... for a small fee.
Kill 10 Battery Bums.
Beat everything in Hard mode with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the Void with Jacob and Esau.
Complete the Corpse with the Forgotten.
Complete the Corpse with Apollyon.
Complete the Corpse with Lazarus.
Complete the Corpse with the Lost.
Complete the Corpse with ???.
Complete the Corpse with Azazel.
Complete the Corpse with Lilith.
Complete the Corpse with Keeper.
Complete the Corpse with Eve.
Complete the Corpse with Samson.
Complete the Corpse with Cain.
Complete the Corpse with Magdalene.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Beat everything in Hard mode with Bethany.
Complete the Corpse with Bethany.
Complete the Corpse with Jacob and Esau.
Complete the Chest with Bethany.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Bethany.
Complete the Cathedral with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete Boss Rush with Bethany.
Complete the final chapter with the Forgotten.
Complete the final chapter with Apollyon.
Complete the final chapter with Lilith.
Complete the final chapter with Lazarus.
Complete the final chapter with Samson.
Kill Hornfel before he escapes!
Complete the final chapter with Bethany.
Complete the final chapter with Keeper.
Complete the final chapter with Cain.
Kids shouldn't believe in fortunes...
Complete the Corpse with Eden.
Complete the Corpse with Judas.
Complete the final chapter with Magdalene.
Complete the final chapter with ???.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete the final chapter with Azazel.
Complete the final chapter with Eden.
Complete the final chapter with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with Judas.
Complete the final chapter with Eve.
Spend 40+ pennies in a single shop.
Obtain 99 pennies. Then spend every single one of them.
Make a new friend!
Complete the final chapter with the Lost.
Defeat Baby Plum 10 times.
Complete the final chapter with Isaac.
The other side is calling...
Defeat all bosses in the Mines.
You are just like your father...
Complete the Corpse with Isaac.
Where could it lead to?
Enter the Corpse...
Defeat all bosses in the Mausoleum.
Beat the Void with Bethany.
Complete ??? with Bethany.
Beat the game in Hard mode with Bethany.
Defeat all bosses in Downpour.
Beat Hard mode as Lazarus without losing a life
Get that song out of her head.
Complete ??? 3 times.