Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
111% now stop playing!
OMG!
Unlocked a new co-player baby.
New mode unlocked!
Built him out of meat cubes.
Unlocked a new character.
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
Unlocked Challenge #11.
Beat basement without taking damage.
New boss in the womb!
Beat Chest or Dark Room without taking damage.
Donated 600 pennies to the shop.
You are the best!!
Beat caves without taking damage.
Isaac now holds the D6!
Unlocked Challenge #19.
Donated 200 pennies to the shop.
They are waiting.
Unlocked a new boss!
You became Lord of the Flies.
Beat womb without taking damage.
Beat depths without taking damage.
New boss in the caves!
New boss in the basement!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
New boss in the depths!
Unlocked Challenge #9.
The game just got harder!
Donated 100 pennies to the shop.
Unlocked Challenge #6.
Unlocked another miniboss!
Unlocked Challenge #8.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Donated 20 pennies to the shop.
Unlocked Challenge #5.
Unlocked Challenge #10.
Destroy 100 rocks.
Unlocked...
Unlocked a new starting item.
Nerd x 1000000
Unlocked a new item
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
Beat Greedier mode with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Beat everything in Hard Mode as every character.
Beat Greed mode with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete the Void with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat Greedier mode with Bethany.
Beat everything in Hard mode with Bethany.
Beat Greed mode with Bethany.
Complete the Corpse with Bethany.
Complete the Corpse with the Forgotten.
Complete the Corpse with Keeper.
Complete the final chapter with Keeper.
Complete the Corpse with the Lost.
Complete the Corpse with Lilith.
Complete the Corpse with Lazarus.
Complete the Corpse with Samson.
Complete the Corpse with Eve.
Complete the Corpse with ???.
Complete the final chapter with the Lost.
Complete the Corpse with Apollyon.
Complete the final chapter with Eden.
Complete the Corpse with Eden.
They will charge you up... for a small fee.
Complete the Corpse with Judas.
Complete the Corpse with Cain.
Complete the Corpse with Magdalene.
Complete the final chapter with Bethany.
Complete the final chapter with the Forgotten.
Complete the final chapter with Apollyon.
Complete the final chapter with Lilith.
Complete the final chapter with Lazarus.
Complete the final chapter with Samson.
Complete the final chapter with Eve.
Complete the final chapter with ???.
Complete the final chapter with Judas.
Complete the final chapter with Cain.
Complete the final chapter with Magdalene.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the Void with Bethany.
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete ??? with Bethany.
Kill 10 Battery Bums.
Make a new friend!
Defeat all bosses in the Mausoleum.
Defeat all bosses in the Mines.
Defeat all bosses in Downpour.
Complete the final chapter with Isaac.
Beat the game in Hard mode with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Obtain 99 pennies. Then spend every single one of them.
Complete the Corpse with Isaac.
Get that song out of her head.
Complete the final chapter with Azazel.
The other side is calling...
You are just like your father...
Complete the Corpse with Azazel.
Where could it lead to?
Enter the Corpse...
Spend 40+ pennies in a single shop.
Kill Hornfel before he escapes!
Complete ??? 3 times.
Defeat Baby Plum 10 times.
Kids shouldn't believe in fortunes...
Beat the game in Hard mode with Bethany.
Complete Boss Rush with Bethany.
Beat Hard mode as Lazarus without losing a life