Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
OMG!
111% now stop playing!
Unlocked a new co-player baby.
Beat caves without taking damage.
Beat womb without taking damage.
Beat Chest or Dark Room without taking damage.
New boss in the womb!
You are the best!!
Isaac now holds the D6!
New boss in the caves!
Unlocked Challenge #11.
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked Challenge #19.
Unlocked Challenge #9.
Beat depths without taking damage.
Unlocked a new boss!
They are waiting.
New boss in the depths!
Beat basement without taking damage.
New boss in the basement!
Donated 600 pennies to the shop.
Donated 200 pennies to the shop.
The game just got harder!
Unlocked Challenge #6.
Built him out of meat cubes.
You became Lord of the Flies.
Donated 100 pennies to the shop.
Unlocked Challenge #8.
Unlocked another miniboss!
Donated 20 pennies to the shop.
Unlocked Challenge #5.
Unlocked Challenge #10.
Destroy 100 rocks.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Nerd x 1000000
Unlocked...
Unlocked a new starting item.
Unlocked a new item
Unlocked Challenge #24.
Unlocked Challenge #27.
Unlocked Challenge #26.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked a new challenge.
Unlocked the power of RERUN.
Unlocked a new area.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Keeper.
Complete the final chapter with ???.
Complete the Corpse with ???.
Complete the Corpse with Lazarus.
Complete the final chapter with Apollyon.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the final chapter with the Lost.
Complete the final chapter with Magdalene.
Complete the final chapter with Lazarus.
Complete the Corpse with Samson.
Complete the Corpse with the Forgotten.
Complete the Corpse with Eden.
Complete the Corpse with Eve.
Complete the final chapter with Cain.
Complete the Corpse with the Lost.
Complete the Corpse with Judas.
Complete the final chapter with Judas.
Beat everything in Hard mode with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete the Corpse with Lilith.
Complete the Corpse with Magdalene.
Complete the Void with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the Corpse with Keeper.
Complete the Corpse with Isaac.
Beat the Void with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Complete the final chapter with Samson.
Complete the final chapter with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the Corpse with Bethany.
Complete the final chapter with Eve.
Complete the final chapter with the Forgotten.
Kids shouldn't believe in fortunes...
Complete the final chapter with Eden.
They will charge you up... for a small fee.
Defeat Baby Plum 10 times.
Complete the Corpse with Cain.
Complete the final chapter with Isaac.
Obtain 99 pennies. Then spend every single one of them.
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Beat the game in Hard mode with Bethany.
Complete the final chapter with Lilith.
Kill 10 Battery Bums.
Complete the final chapter with Bethany.
Complete the Corpse with Apollyon.
Beat Greedier mode with Bethany.
Beat Greed mode with Bethany.
Make a new friend!
Beat Hard mode as Lazarus without losing a life
Complete the final chapter with Azazel.
The other side is calling...
Spend 40+ pennies in a single shop.
You are just like your father...
Complete the Corpse with Azazel.
Where could it lead to?
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Defeat all bosses in the Mausoleum.
Enter the Corpse...
Get that song out of her head.
Defeat all bosses in Downpour.
Complete ??? 3 times.