Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Unlocked new enemies!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
111% now stop playing!
OMG!
Isaac now holds the D6!
Unlocked a new co-player baby.
Unlocked Challenge #11.
Unlocked Challenge #19.
Beat Chest or Dark Room without taking damage.
Beat depths without taking damage.
New boss in the womb!
You became Lord of the Flies.
You are the best!!
Built him out of meat cubes.
They are waiting.
Donated 600 pennies to the shop.
Beat womb without taking damage.
New boss in the depths!
Unlocked Challenge #8.
New boss in the caves!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Beat caves without taking damage.
New boss in the basement!
Unlocked Challenge #9.
Unlocked a new boss!
The game just got harder!
Unlocked another miniboss!
Beat basement without taking damage.
Unlocked Challenge #6.
Donated 200 pennies to the shop.
Donated 100 pennies to the shop.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Unlocked Challenge #5.
Unlocked Challenge #10.
Destroy 100 rocks.
Donated 20 pennies to the shop.
Nerd x 1000000
Unlocked a new starting item.
Unlocked...
Unlocked a new item
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked a new area.
Unlocked the power of RERUN.
Unlocked a new challenge.
Complete the final chapter with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
They will charge you up... for a small fee.
Complete Sheol with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete ??? with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete the Corpse with ???.
Complete the final chapter with ???.
Kill 10 Battery Bums.
Complete the final chapter with Judas.
Kids shouldn't believe in fortunes...
Complete the Corpse with Cain.
Complete the Corpse with Eden.
Complete the final chapter with Cain.
Beat the game in Hard mode with Jacob and Esau.
Complete the final chapter with Eden.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the final chapter with Magdalene.
Complete the Corpse with Magdalene.
Complete the Corpse with Isaac.
Complete the final chapter with Isaac.
Defeat Baby Plum 10 times.
Complete the final chapter with Azazel.
Beat everything in Hard mode with Bethany.
Complete the final chapter with Bethany.
The other side is calling...
Complete the Corpse with Bethany.
You are just like your father...
Complete the Corpse with Azazel.
Where could it lead to?
Defeat all bosses in the Mines.
Obtain 99 pennies. Then spend every single one of them.
Defeat all bosses in the Mausoleum.
Spend 40+ pennies in a single shop.
Get that song out of her head.
Beat the Void with Bethany.
Complete ??? with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Complete Boss Rush with Bethany.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Make a new friend!
Enter the Corpse...
Kill Hornfel before he escapes!
Defeat all bosses in Downpour.
Complete ??? 3 times.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Complete the Corpse with Judas.
Complete the Corpse with Eve.
Complete the final chapter with Eve.
Complete the Corpse with Samson.
Complete the final chapter with Samson.
Complete the Corpse with Lazarus.
Complete the final chapter with Lazarus.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Complete the Corpse with Lilith.
Complete the final chapter with Lilith.
Complete the Corpse with Keeper.
Complete the final chapter with Keeper.
Complete the Corpse with Apollyon.
Complete the final chapter with Apollyon.
Complete the Corpse with the Forgotten.
Complete the final chapter with the Forgotten.
Complete the Corpse with Jacob and Esau.
Beat everything in Hard Mode as every character.