Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
111% now stop playing!
Unlocked Challenge #11.
Unlocked a new co-player baby.
Built him out of meat cubes.
OMG!
Donated 600 pennies to the shop.
Donated 200 pennies to the shop.
Beat Chest or Dark Room without taking damage.
Beat depths without taking damage.
Beat caves without taking damage.
Beat womb without taking damage.
Unlocked Challenge #8.
You are the best!!
Unlocked Challenge #19.
New boss in the womb!
Isaac now holds the D6!
They are waiting.
You became Lord of the Flies.
Unlocked Challenge #4.
Unlocked Challenge #7.
Your future's past waits.
New boss in the depths!
New boss in the caves!
Unlocked Challenge #9.
Unlocked a new boss!
The game just got harder!
New boss in the basement!
Unlocked another miniboss!
Unlocked Challenge #6.
Donated 100 pennies to the shop.
Donated 20 pennies to the shop.
Unlocked Challenge #5.
Unlocked Challenge #10.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Beat basement without taking damage.
Destroy 100 rocks.
Nerd x 1000000
Unlocked a new starting item.
Unlocked...
Unlocked a new item
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
They will charge you up... for a small fee.
Make a new friend!
Beat everything in Hard mode with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Beat everything in Hard Mode as every character.
Beat everything in Hard mode with Bethany.
Complete the Corpse with Bethany.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Complete the Corpse with the Forgotten.
Complete the Corpse with Keeper.
Complete the final chapter with Azazel.
Complete the Corpse with Eve.
Complete the final chapter with Keeper.
Complete the Corpse with Samson.
Complete the final chapter with ???.
Complete the Corpse with Lilith.
Kids shouldn't believe in fortunes...
Complete the final chapter with Bethany.
Complete Boss Rush with Bethany.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with Lazarus.
Complete the final chapter with the Lost.
Complete the final chapter with Apollyon.
Complete the final chapter with the Forgotten.
Complete the final chapter with Judas.
Complete the final chapter with Cain.
Complete Sheol with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete the Corpse with Magdalene.
Complete the final chapter with Magdalene.
Complete the Corpse with Eden.
Complete the final chapter with Eden.
Kill 10 Battery Bums.
Complete the final chapter with Eve.
Complete the final chapter with Samson.
Beat the Void with Bethany.
Complete ??? with Jacob and Esau.
Complete ??? with Bethany.
Defeat Mega Satan with Bethany.
Defeat Mega Satan with Jacob and Esau.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Complete the Corpse with Cain.
Complete the Corpse with ???.
Complete the Corpse with Judas.
Complete the Corpse with Apollyon.
Complete the Void with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Obtain 99 pennies. Then spend every single one of them.
Spend 40+ pennies in a single shop.
Complete the final chapter with Lilith.
Complete the final chapter with Jacob and Esau.
Beat Hard mode as Lazarus without losing a life
Get that song out of her head.
Defeat Baby Plum 10 times.
Defeat all bosses in the Mines.
Complete the final chapter with Isaac.
Complete the Corpse with Azazel.
Complete the Corpse with Lazarus.
Complete the Corpse with the Lost.
Defeat all bosses in Downpour.
The other side is calling...
Defeat all bosses in the Mausoleum.
You are just like your father...
Where could it lead to?
Complete the Corpse with Isaac.
Enter the Corpse...
Kill Hornfel before he escapes!
Complete ??? 3 times.