Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Beat depths without taking damage.
New mode unlocked!
Built him out of meat cubes.
Unlocked a new character.
Unlocked new enemies!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked a new co-player baby.
Donated 600 pennies to the shop.
Beat caves without taking damage.
Beat womb without taking damage.
You are the best!!
New boss in the womb!
Unlocked Challenge #19.
They are waiting.
Isaac now holds the D6!
You became Lord of the Flies.
New boss in the caves!
Unlocked another miniboss!
Unlocked Challenge #8.
New boss in the basement!
New boss in the depths!
Unlocked Challenge #4.
Unlocked Challenge #7.
Your future's past waits.
Unlocked Challenge #9.
Unlocked a new boss!
The game just got harder!
Donated 200 pennies to the shop.
Beat basement without taking damage.
Donated 100 pennies to the shop.
Unlocked Challenge #6.
Donated 20 pennies to the shop.
Unlocked Challenge #5.
Unlocked Challenge #10.
Destroy 100 rocks.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
OMG!
Beat Chest or Dark Room without taking damage.
111% now stop playing!
Unlocked Challenge #11.
Unlocked a new item
Nerd x 1000000
Unlocked a new starting item.
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked Challenge #21.
Unlocked...
Unlocked a new challenge.
Unlocked a new area.
Unlocked super special rocks.
Unlocked the power of RERUN.
Complete the Corpse with Apollyon.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Complete the Corpse with Lazarus.
Complete the Corpse with Eden.
Beat the Void with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Complete the final chapter with Eve.
Complete the Corpse with ???.
Complete the Dark Room with Bethany.
Complete the final chapter with Eden.
Complete the final chapter with Azazel.
Complete the final chapter with Magdalene.
Complete the Corpse with Judas.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete the final chapter with Bethany.
Complete the final chapter with Judas.
Complete the final chapter with ???.
Complete the final chapter with Samson.
Complete the Corpse with Samson.
Complete the final chapter with Cain.
Complete the Corpse with Eve.
Complete the final chapter with Isaac.
The other side is calling...
Complete the Corpse with Azazel.
Get that song out of her head.
Complete the Corpse with Cain.
Complete the Corpse with Magdalene.
Defeat all bosses in the Mines.
You are just like your father...
Complete the Corpse with Isaac.
Where could it lead to?
Defeat all bosses in the Mausoleum.
Make a new friend!
Complete Sheol with Bethany.
Beat the game in Hard mode with Bethany.
Kids shouldn't believe in fortunes...
Enter the Corpse...
Kill Hornfel before he escapes!
Defeat all bosses in Downpour.
Complete ??? 3 times.
Obtain 99 pennies. Then spend every single one of them.
Kill 10 Battery Bums.
Spend 40+ pennies in a single shop.
Beat Hard mode as Lazarus without losing a life
Defeat Baby Plum 10 times.
Beat everything in Hard mode with Bethany.
Defeat Mega Satan with Bethany.
Beat the game in Hard mode with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the final chapter with Lazarus.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Complete the Corpse with Lilith.
Complete the final chapter with Lilith.
Complete the Corpse with Keeper.
Complete the final chapter with Keeper.
Complete the final chapter with Apollyon.
Complete the Corpse with the Forgotten.
Complete the final chapter with the Forgotten.
Complete the Corpse with Bethany.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
They will charge you up... for a small fee.
Beat everything in Hard Mode as every character.