Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
111% now stop playing!
OMG!
Unlocked a new co-player baby.
Unlocked a new character.
New mode unlocked!
Unlocked new enemies!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Built him out of meat cubes.
Beat Chest or Dark Room without taking damage.
Donated 600 pennies to the shop.
Unlocked Challenge #11.
New boss in the womb!
Unlocked Challenge #19.
Isaac now holds the D6!
Beat depths without taking damage.
You are the best!!
They are waiting.
Unlocked a new boss!
Donated 200 pennies to the shop.
Beat womb without taking damage.
New boss in the caves!
Beat caves without taking damage.
New boss in the depths!
New boss in the basement!
Unlocked Challenge #4.
Unlocked Challenge #7.
Your future's past waits.
Unlocked Challenge #8.
Donated 100 pennies to the shop.
Unlocked Challenge #9.
You became Lord of the Flies.
The game just got harder!
Unlocked another miniboss!
Unlocked Challenge #6.
Donated 20 pennies to the shop.
Destroy 100 rocks.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Unlocked Challenge #5.
Unlocked Challenge #10.
Beat basement without taking damage.
Unlocked...
Unlocked a new item
Unlocked a new starting item.
Nerd x 1000000
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked Challenge #21.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
They will charge you up... for a small fee.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the Void with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with Apollyon.
Complete ??? with Jacob and Esau.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Beat everything in Hard mode with Bethany.
Complete the Corpse with ???.
Complete the Corpse with Jacob and Esau.
Complete the Corpse with Bethany.
Complete the Corpse with Samson.
Complete the final chapter with Jacob and Esau.
Complete the final chapter with Magdalene.
Complete the Corpse with Eden.
Complete the Corpse with Magdalene.
Complete the Corpse with Keeper.
Complete the Corpse with Eve.
Complete the final chapter with Eve.
Complete the Corpse with the Forgotten.
Complete the final chapter with Keeper.
Complete the final chapter with Eden.
Complete the final chapter with Isaac.
Complete the final chapter with Lilith.
Complete the Corpse with Lilith.
Complete the final chapter with the Forgotten.
Beat the Void with Bethany.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete the final chapter with Judas.
Obtain 99 pennies. Then spend every single one of them.
Complete the Corpse with Cain.
Complete the Corpse with Lazarus.
Make a new friend!
Complete the Dark Room with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Beat the game in Hard mode with Bethany.
Complete the final chapter with Apollyon.
Complete the final chapter with Lazarus.
Complete the final chapter with Bethany.
Complete the final chapter with ???.
Complete the final chapter with Samson.
Complete the final chapter with Cain.
Complete the Corpse with Isaac.
Kill 10 Battery Bums.
Complete the final chapter with the Lost.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete the Corpse with the Lost.
Complete Boss Rush with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the final chapter with Azazel.
Complete the Corpse with Judas.
Kids shouldn't believe in fortunes...
The other side is calling...
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Defeat all bosses in the Mausoleum.
Defeat Baby Plum 10 times.
Beat Hard mode as Lazarus without losing a life
You are just like your father...
Where could it lead to?
Complete the Corpse with Azazel.
Get that song out of her head.
Enter the Corpse...
Spend 40+ pennies in a single shop.
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Defeat all bosses in Downpour.
Complete ??? 3 times.