Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
OMG!
111% now stop playing!
Unlocked a new item.
Unlocked a new co-player baby.
Beat Chest or Dark Room without taking damage.
New mode unlocked!
Unlocked Challenge #8.
Unlocked a new character.
Unlocked Challenge #11.
Beat depths without taking damage.
Unlocked even more bosses!
Donated 600 pennies to the shop.
Built him out of meat cubes.
You are the best!!
Unlocked new enemies!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
New boss in the womb!
Beat womb without taking damage.
Unlocked Challenge #19.
They are waiting.
Isaac now holds the D6!
You became Lord of the Flies.
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked a new boss!
Beat caves without taking damage.
Unlocked Challenge #9.
New boss in the depths!
New boss in the caves!
The game just got harder!
Donated 200 pennies to the shop.
Unlocked another miniboss!
Unlocked Challenge #6.
New boss in the basement!
Unlocked Challenge #5.
Unlocked Challenge #10.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Donated 100 pennies to the shop.
Beat basement without taking damage.
Donated 20 pennies to the shop.
Destroy 100 rocks.
Unlocked a new starting item.
Unlocked a secret.
Unlocked a new item
Nerd x 1000000
Greed just got harder!
Unlocked Challenge #24.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked...
Unlocked super special rocks.
Unlocked a new area.
Unlocked the power of RERUN.
Unlocked a new challenge.
Complete the Void with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Complete the final chapter with the Forgotten.
Complete the Corpse with the Forgotten.
Beat Greedier mode with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
They will charge you up... for a small fee.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Corpse with Apollyon.
Complete the Corpse with Eden.
Complete the Corpse with Keeper.
Complete the final chapter with Keeper.
Complete the final chapter with Apollyon.
Complete the Corpse with Lilith.
Complete the final chapter with Eden.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the final chapter with Lilith.
Complete the final chapter with Eve.
Complete the Corpse with Eve.
Complete the Corpse with Lazarus.
Beat everything in Hard mode with Bethany.
Complete the final chapter with Bethany.
Kill 10 Battery Bums.
Beat Greedier mode with Bethany.
Complete the final chapter with Lazarus.
Complete ??? with Bethany.
Complete the Corpse with ???.
Complete the Corpse with Judas.
Complete the Corpse with Bethany.
Complete the Corpse with Magdalene.
Get that song out of her head.
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Beat the game in Hard mode with Bethany.
Beat the Void with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Kids shouldn't believe in fortunes...
Complete the Corpse with Isaac.
Complete the Corpse with Samson.
Complete the final chapter with Samson.
Complete Boss Rush with Jacob and Esau.
Complete the Corpse with Cain.
Complete the final chapter with Judas.
Complete the final chapter with Magdalene.
Complete the final chapter with Isaac.
Complete the final chapter with Cain.
Beat Greed mode with Bethany.
Make a new friend!
Complete the final chapter with ???.
Spend 40+ pennies in a single shop.
Complete the final chapter with Azazel.
Complete Boss Rush with Bethany.
Beat Hard mode as Lazarus without losing a life
The other side is calling...
Defeat Baby Plum 10 times.
You are just like your father...
Where could it lead to?
Complete the Corpse with Azazel.
Defeat all bosses in the Mausoleum.
Obtain 99 pennies. Then spend every single one of them.
Enter the Corpse...
Kill Hornfel before he escapes!
Defeat all bosses in the Mines.
Defeat all bosses in Downpour.
Complete ??? 3 times.
Complete ??? with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Beat everything in Hard Mode as every character.