Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new co-player baby.
Unlocked Challenge #11.
New mode unlocked!
Unlocked a new character.
Beat Chest or Dark Room without taking damage.
Donated 600 pennies to the shop.
Beat depths without taking damage.
You are the best!!
Unlocked new enemies!
Unlocked even more bosses!
Alt stage to the womb.
Isaac now holds the D6!
Donated 200 pennies to the shop.
Unlocked new bosses!
New boss in the womb!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Unlocked Challenge #19.
They are waiting.
Unlocked a new boss!
Built him out of meat cubes.
Beat womb without taking damage.
Unlocked Challenge #4.
Unlocked Challenge #7.
Your future's past waits.
Donated 100 pennies to the shop.
Unlocked Challenge #9.
New boss in the caves!
New boss in the basement!
The game just got harder!
New boss in the depths!
You became Lord of the Flies.
Unlocked Challenge #6.
Donated 20 pennies to the shop.
Beat caves without taking damage.
Unlocked another miniboss!
Unlocked Challenge #5.
Unlocked Challenge #10.
Beat basement without taking damage.
Destroy 100 rocks.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
OMG!
111% now stop playing!
Unlocked Challenge #8.
Unlocked a new starting item.
Nerd x 1000000
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #24.
Unlocked a new item
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked...
Unlocked super special rocks.
Unlocked a new challenge.
Unlocked a new area.
Unlocked the power of RERUN.
Complete the Corpse with Eden.
Beat Greedier mode with Bethany.
Kill 10 Battery Bums.
Obtain 99 pennies. Then spend every single one of them.
Beat Greed mode with Bethany.
Complete the final chapter with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Spend 40+ pennies in a single shop.
Complete the final chapter with the Forgotten.
Defeat Baby Plum 10 times.
Complete the Corpse with the Forgotten.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Kids shouldn't believe in fortunes...
Complete the Cathedral with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Beat the game in Hard mode with Bethany.
Complete the final chapter with Azazel.
The other side is calling...
Beat the game in Hard mode with Jacob and Esau.
You are just like your father...
Complete the Corpse with Isaac.
Where could it lead to?
Enter the Corpse...
Defeat all bosses in the Mines.
Defeat all bosses in Downpour.
Beat Hard mode as Lazarus without losing a life
Get that song out of her head.
Complete ??? 3 times.
Make a new friend!
Defeat all bosses in the Mausoleum.
Beat the Void with Bethany.
Beat everything in Hard mode with Bethany.
Complete the Cathedral with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the final chapter with Isaac.
Complete the Corpse with Magdalene.
Complete the final chapter with Magdalene.
Complete the Corpse with Cain.
Complete the final chapter with Cain.
Complete the Corpse with Judas.
Complete the final chapter with Judas.
Complete the Corpse with ???.
Complete the final chapter with ???.
Complete the Corpse with Eve.
Complete the final chapter with Eve.
Complete the Corpse with Samson.
Complete the final chapter with Samson.
Complete the Corpse with Azazel.
Complete the Corpse with Lazarus.
Complete the final chapter with Lazarus.
Complete the final chapter with Eden.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Complete the Corpse with Lilith.
Complete the final chapter with Lilith.
Complete the Corpse with Keeper.
Complete the final chapter with Keeper.
Complete the Corpse with Apollyon.
Complete the final chapter with Apollyon.
Complete the Corpse with Bethany.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
They will charge you up... for a small fee.
Kill Hornfel before he escapes!
Beat everything in Hard Mode as every character.