Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
New mode unlocked!
Alt stage to the womb.
Unlocked even more bosses!
Unlocked new bosses!
Unlocked a new character.
Alt stage to the depths.
Alt stage to the caves.
Alt stage to the basement.
Unlocked new enemies!
111% now stop playing!
OMG!
Unlocked a new co-player baby.
Beat Chest or Dark Room without taking damage.
Unlocked Challenge #11.
New boss in the womb!
Unlocked Challenge #19.
Donated 600 pennies to the shop.
Built him out of meat cubes.
You are the best!!
Beat womb without taking damage.
Unlocked Challenge #8.
Isaac now holds the D6!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
They are waiting.
Unlocked Challenge #9.
Beat caves without taking damage.
Unlocked a new boss!
New boss in the caves!
You became Lord of the Flies.
New boss in the depths!
Donated 200 pennies to the shop.
New boss in the basement!
Beat depths without taking damage.
The game just got harder!
Donated 100 pennies to the shop.
Unlocked another miniboss!
Unlocked Challenge #6.
Donated 20 pennies to the shop.
Destroy 100 rocks.
Unlocked Challenge #5.
Unlocked Challenge #10.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Beat basement without taking damage.
Nerd x 1000000
Unlocked...
Unlocked a new starting item.
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #24.
Unlocked a hidden chapter.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked a new item
Unlocked Challenge #23.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
Beat everything in Hard Mode as every character.
Beat everything in Hard mode with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Complete the final chapter with Keeper.
Complete the final chapter with Lilith.
Complete the Corpse with Apollyon.
Complete the Corpse with Lilith.
Complete the Corpse with Lazarus.
Complete the Corpse with Keeper.
Complete the Void with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat everything in Hard mode with Bethany.
Complete the final chapter with Bethany.
Complete ??? with Bethany.
Complete the Corpse with Jacob and Esau.
Complete the Corpse with Bethany.
Complete Boss Rush with Bethany.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the Corpse with Eden.
Complete the final chapter with Azazel.
Complete the Corpse with Eve.
Complete the Corpse with ???.
Complete the final chapter with Judas.
Complete the Corpse with Magdalene.
Complete the Corpse with the Lost.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Beat Greedier mode with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the final chapter with the Lost.
They will charge you up... for a small fee.
Beat the Void with Bethany.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete the final chapter with the Forgotten.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete the Corpse with Judas.
Make a new friend!
Complete the Corpse with the Forgotten.
Complete the final chapter with Samson.
Complete the final chapter with Apollyon.
Complete the final chapter with Lazarus.
Complete the final chapter with Eve.
Complete the final chapter with Magdalene.
Complete the final chapter with ???.
Obtain 99 pennies. Then spend every single one of them.
Complete the Corpse with Isaac.
Kill 10 Battery Bums.
Complete the final chapter with Isaac.
Kids shouldn't believe in fortunes...
Complete the final chapter with Eden.
Complete the final chapter with Cain.
The other side is calling...
Complete the Corpse with Samson.
Complete the Corpse with Azazel.
Defeat all bosses in the Mines.
Defeat all bosses in the Mausoleum.
Defeat all bosses in Downpour.
You are just like your father...
Where could it lead to?
Complete the Corpse with Cain.
Enter the Corpse...
Kill Hornfel before he escapes!
Get that song out of her head.
Defeat Baby Plum 10 times.
Spend 40+ pennies in a single shop.
Complete ??? 3 times.
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life