Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
OMG!
111% now stop playing!
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
Donated 600 pennies to the shop.
Unlocked Challenge #11.
Unlocked a new co-player baby.
Beat caves without taking damage.
Beat Chest or Dark Room without taking damage.
Beat depths without taking damage.
Beat womb without taking damage.
Isaac now holds the D6!
You are the best!!
You became Lord of the Flies.
New boss in the womb!
Built him out of meat cubes.
Unlocked Challenge #19.
Unlocked a new boss!
They are waiting.
New boss in the caves!
Donated 200 pennies to the shop.
New boss in the basement!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
New boss in the depths!
Unlocked Challenge #9.
The game just got harder!
Unlocked another miniboss!
Donated 100 pennies to the shop.
Beat basement without taking damage.
Unlocked Challenge #6.
Unlocked Challenge #8.
Destroy 100 rocks.
Donated 20 pennies to the shop.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Unlocked Challenge #5.
Unlocked Challenge #10.
Unlocked...
Nerd x 1000000
Unlocked a new starting item.
Unlocked a new item
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #26.
Unlocked a hidden chapter.
Unlocked Challenge #24.
Unlocked Challenge #27.
Unlocked Challenge #23.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
Get that song out of her head.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Kill 10 Battery Bums.
Beat the game in Hard mode with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the Corpse with the Lost.
Complete the Corpse with Lilith.
Complete the Corpse with Keeper.
Complete the Corpse with Apollyon.
Make a new friend!
Complete the Corpse with the Forgotten.
Complete the final chapter with Keeper.
Complete the Corpse with Bethany.
Complete the final chapter with Bethany.
Complete the Dark Room with Bethany.
Complete ??? with Bethany.
Beat the Void with Bethany.
Complete the final chapter with Lilith.
Obtain 99 pennies. Then spend every single one of them.
Complete the final chapter with the Forgotten.
Complete the final chapter with the Lost.
Complete the Corpse with ???.
Kids shouldn't believe in fortunes...
Complete the Corpse with Eve.
Complete the Corpse with Lazarus.
Complete the final chapter with Lazarus.
Complete the final chapter with ???.
Complete the Corpse with Samson.
Complete the final chapter with Samson.
Complete the Corpse with Eden.
Complete the Corpse with Judas.
Complete the Corpse with Cain.
Complete the Corpse with Magdalene.
Complete the Corpse with Isaac.
Complete the final chapter with Apollyon.
Complete the final chapter with Eve.
Complete the final chapter with Eden.
Complete the final chapter with Cain.
Complete the final chapter with Isaac.
Complete the final chapter with Judas.
Defeat Baby Plum 10 times.
Spend 40+ pennies in a single shop.
Complete the final chapter with Magdalene.
Complete the final chapter with Azazel.
The other side is calling...
You are just like your father...
Complete the Corpse with Azazel.
Where could it lead to?
Enter the Corpse...
Kill Hornfel before he escapes!
Defeat all bosses in the Mines.
Defeat Mega Satan with Bethany.
Complete Sheol with Bethany.
Complete Boss Rush with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Defeat all bosses in the Mausoleum.
Defeat all bosses in Downpour.
Beat Hard mode as Lazarus without losing a life
Complete ??? 3 times.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Beat everything in Hard mode with Bethany.
Complete Sheol with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
They will charge you up... for a small fee.
Beat everything in Hard Mode as every character.