Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
111% now stop playing!
OMG!
Unlocked Challenge #11.
Unlocked a new co-player baby.
Built him out of meat cubes.
You became Lord of the Flies.
Donated 600 pennies to the shop.
Beat Chest or Dark Room without taking damage.
New boss in the womb!
Unlocked Challenge #19.
You are the best!!
They are waiting.
Isaac now holds the D6!
Unlocked a new boss!
New boss in the caves!
New boss in the basement!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked Challenge #9.
Donated 200 pennies to the shop.
New boss in the depths!
Beat womb without taking damage.
The game just got harder!
Beat caves without taking damage.
Unlocked Challenge #5.
Unlocked Challenge #10.
Unlocked Challenge #6.
Beat depths without taking damage.
Donated 100 pennies to the shop.
Unlocked another miniboss!
Beat basement without taking damage.
Donated 20 pennies to the shop.
Unlocked Challenge #8.
Destroy 100 rocks.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Nerd x 1000000
Unlocked...
Unlocked a new starting item.
Unlocked a secret.
Greed just got harder!
Unlocked a new item
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
Beat the game in Hard mode with Jacob and Esau.
Beat everything in Hard mode with Bethany.
Complete the final chapter with Bethany.
Beat Greedier mode with Bethany.
Complete the Corpse with Lilith.
Complete the final chapter with the Lost.
Complete the Corpse with the Lost.
Kill 10 Battery Bums.
Complete the Corpse with Bethany.
Complete the Corpse with Apollyon.
Complete the final chapter with Apollyon.
Complete the Corpse with Eden.
Complete the final chapter with Eden.
Complete the final chapter with Lilith.
Complete the final chapter with the Forgotten.
Complete the Corpse with the Forgotten.
Beat Greed mode with Jacob and Esau.
Complete the Corpse with Lazarus.
Complete the final chapter with Lazarus.
Complete the final chapter with Azazel.
Complete the Corpse with Samson.
Complete the final chapter with Samson.
Complete the Corpse with Eve.
Complete the final chapter with Eve.
Complete the final chapter with ???.
Complete the Corpse with ???.
Complete the final chapter with Judas.
Complete the Corpse with Judas.
Complete the final chapter with Cain.
Complete the Corpse with Cain.
Complete the Corpse with Magdalene.
Make a new friend!
Complete the final chapter with Magdalene.
Complete the final chapter with Isaac.
The other side is calling...
Beat Greed mode with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete Boss Rush with Bethany.
Complete ??? with Bethany.
Beat the Void with Bethany.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Obtain 99 pennies. Then spend every single one of them.
Kids shouldn't believe in fortunes...
Defeat Baby Plum 10 times.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Complete the Corpse with Azazel.
You are just like your father...
Complete the Corpse with Isaac.
Where could it lead to?
Defeat all bosses in the Mausoleum.
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Spend 40+ pennies in a single shop.
Enter the Corpse...
Get that song out of her head.
Defeat all bosses in Downpour.
Complete ??? 3 times.
Complete the Cathedral with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with Keeper.
Complete the final chapter with Keeper.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
They will charge you up... for a small fee.
Beat everything in Hard Mode as every character.