Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
111% now stop playing!
OMG!
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
Unlocked a new co-player baby.
Beat depths without taking damage.
Beat Chest or Dark Room without taking damage.
Beat womb without taking damage.
Donated 600 pennies to the shop.
Unlocked Challenge #11.
New boss in the womb!
You are the best!!
Donated 200 pennies to the shop.
Unlocked a new boss!
Unlocked Challenge #19.
Beat caves without taking damage.
New boss in the basement!
They are waiting.
New boss in the caves!
New boss in the depths!
Isaac now holds the D6!
Donated 100 pennies to the shop.
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked Challenge #9.
Built him out of meat cubes.
The game just got harder!
Unlocked another miniboss!
You became Lord of the Flies.
Donated 20 pennies to the shop.
Beat basement without taking damage.
Unlocked Challenge #6.
Unlocked Challenge #8.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Unlocked Challenge #5.
Unlocked Challenge #10.
Destroy 100 rocks.
Nerd x 1000000
Unlocked...
Unlocked a new starting item.
Unlocked a secret.
Greed just got harder!
Unlocked a new item
Unlocked a hidden chapter.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked Challenge #21.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
They will charge you up... for a small fee.
Complete the Corpse with Apollyon.
Complete the final chapter with ???.
Complete the Corpse with the Forgotten.
Complete the final chapter with Azazel.
Complete the final chapter with Eden.
Complete the final chapter with the Forgotten.
Complete the final chapter with Judas.
Complete the final chapter with the Lost.
Get that song out of her head.
Complete the final chapter with Cain.
Complete the Corpse with Eden.
Make a new friend!
Complete the final chapter with Isaac.
The other side is calling...
Complete the Corpse with Azazel.
Complete the Corpse with Judas.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Complete the Corpse with the Lost.
Complete the Corpse with Cain.
Complete the Corpse with Isaac.
Defeat Baby Plum 10 times.
You are just like your father...
Where could it lead to?
Complete the Corpse with ???.
Enter the Corpse...
Defeat all bosses in the Mausoleum.
Kill Hornfel before he escapes!
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Spend 40+ pennies in a single shop.
Defeat all bosses in Downpour.
Kids shouldn't believe in fortunes...
Defeat all bosses in the Mines.
Obtain 99 pennies. Then spend every single one of them.
Beat Greedier mode with Bethany.
Beat Greed mode with Bethany.
Beat the Void with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Complete ??? 3 times.
Beat everything in Hard mode with Bethany.
Beat the game in Hard mode with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with Magdalene.
Complete the final chapter with Magdalene.
Complete the Corpse with Eve.
Complete the final chapter with Eve.
Complete the Corpse with Samson.
Complete the final chapter with Samson.
Complete the Corpse with Lazarus.
Complete the final chapter with Lazarus.
Complete the Corpse with Lilith.
Complete the final chapter with Lilith.
Complete the Corpse with Keeper.
Complete the final chapter with Keeper.
Complete the final chapter with Apollyon.
Complete the Corpse with Bethany.
Complete the final chapter with Bethany.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Kill 10 Battery Bums.
Beat everything in Hard Mode as every character.