Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
OMG!
111% now stop playing!
Unlocked a new co-player baby.
Built him out of meat cubes.
Donated 600 pennies to the shop.
New boss in the womb!
Unlocked Challenge #11.
Beat Chest or Dark Room without taking damage.
Beat depths without taking damage.
Beat caves without taking damage.
Isaac now holds the D6!
New boss in the caves!
You are the best!!
Unlocked Challenge #19.
Unlocked a new boss!
They are waiting.
Unlocked Challenge #8.
New boss in the basement!
Unlocked Challenge #4.
Unlocked Challenge #7.
Your future's past waits.
Unlocked Challenge #9.
New boss in the depths!
Donated 200 pennies to the shop.
The game just got harder!
You became Lord of the Flies.
Unlocked Challenge #5.
Unlocked Challenge #10.
Unlocked Challenge #6.
Beat basement without taking damage.
Beat womb without taking damage.
Donated 100 pennies to the shop.
Unlocked another miniboss!
Destroy 100 rocks.
Donated 20 pennies to the shop.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Nerd x 1000000
Unlocked...
Unlocked a new item
Unlocked a new starting item.
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked a hidden chapter.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
Beat everything in Hard Mode as every character.
Complete the final chapter with Lilith.
Complete the Corpse with Lilith.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Complete the final chapter with Lazarus.
Complete the Corpse with Lazarus.
Complete the Corpse with Samson.
Complete the final chapter with Samson.
Complete the final chapter with Magdalene.
Complete the Corpse with Magdalene.
Complete the final chapter with Isaac.
Complete the Corpse with Isaac.
Beat Greedier mode with Bethany.
Beat everything in Hard mode with Bethany.
Beat Greed mode with Bethany.
Beat the Void with Bethany.
Complete the final chapter with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete the Corpse with Bethany.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Complete the final chapter with the Forgotten.
Complete the Chest with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with Azazel.
Complete the Corpse with Azazel.
Complete the final chapter with Keeper.
Complete the Corpse with Keeper.
Complete the final chapter with ???.
Complete the Corpse with ???.
Complete the final chapter with Judas.
They will charge you up... for a small fee.
Complete the Corpse with Judas.
Complete the Void with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the final chapter with Cain.
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete ??? with Bethany.
Beat the game in Hard mode with Bethany.
Complete Boss Rush with Bethany.
Complete the Corpse with Cain.
Complete the Corpse with Eden.
Complete the Corpse with Jacob and Esau.
Kids shouldn't believe in fortunes...
Complete the final chapter with Apollyon.
Make a new friend!
Complete the Corpse with Apollyon.
Kill 10 Battery Bums.
Defeat Baby Plum 10 times.
Complete the final chapter with Eve.
Complete the Corpse with Eve.
Obtain 99 pennies. Then spend every single one of them.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the final chapter with Eden.
The other side is calling...
Where could it lead to?
You are just like your father...
Complete the Corpse with the Forgotten.
Enter the Corpse...
Get that song out of her head.
Defeat all bosses in the Mausoleum.
Spend 40+ pennies in a single shop.
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Defeat all bosses in Downpour.
Beat Hard mode as Lazarus without losing a life
Complete ??? 3 times.