Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked Challenge #11.
Unlocked new enemies!
Alt stage to the womb.
Unlocked a new co-player baby.
Donated 600 pennies to the shop.
You became Lord of the Flies.
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Unlocked Challenge #19.
Unlocked a new boss!
Built him out of meat cubes.
They are waiting.
New boss in the caves!
Unlocked a new character.
New boss in the basement!
Isaac now holds the D6!
New boss in the depths!
Your future's past waits.
Beat basement without taking damage.
Donated 200 pennies to the shop.
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked Challenge #9.
Unlocked another miniboss!
Beat womb without taking damage.
Donated 100 pennies to the shop.
Unlocked Challenge #5.
Unlocked Challenge #10.
The game just got harder!
Unlocked Challenge #6.
Unlocked Challenge #8.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Destroy 100 rocks.
Donated 20 pennies to the shop.
Beat caves without taking damage.
Beat depths without taking damage.
You are the best!!
New boss in the womb!
OMG!
Beat Chest or Dark Room without taking damage.
111% now stop playing!
New mode unlocked!
Unlocked new bosses!
Unlocked even more bosses!
Greed just got harder!
Unlocked a new starting item.
Unlocked Challenge #24.
Unlocked a secret.
Unlocked a hidden chapter.
Unlocked Challenge #27.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked a new item
Unlocked Challenge #26.
Unlocked...
Nerd x 1000000
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked super special rocks.
Unlocked a new challenge.
Complete the Dark Room with Bethany.
Beat Greed mode with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the final chapter with Judas.
Complete the final chapter with Lilith.
Obtain 99 pennies. Then spend every single one of them.
The other side is calling...
You are just like your father...
Complete the Corpse with Eve.
Complete the Corpse with Azazel.
Where could it lead to?
Kill Hornfel before he escapes!
Enter the Corpse...
Defeat all bosses in the Mines.
Kill 10 Battery Bums.
Defeat all bosses in Downpour.
Complete ??? 3 times.
Defeat Baby Plum 10 times.
Complete Sheol with Bethany.
Beat Greed mode with Bethany.
Spend 40+ pennies in a single shop.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Kids shouldn't believe in fortunes...
Get that song out of her head.
Make a new friend!
Defeat all bosses in the Mausoleum.
Complete the Chest with Bethany.
Complete Boss Rush with Bethany.
Complete ??? with Bethany.
Beat Greedier mode with Bethany.
Beat the Void with Bethany.
Beat everything in Hard mode with Bethany.
Defeat Mega Satan with Bethany.
Complete the Cathedral with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with Isaac.
Complete the final chapter with Isaac.
Complete the Corpse with Magdalene.
Complete the final chapter with Magdalene.
Complete the Corpse with Cain.
Complete the final chapter with Cain.
Complete the Corpse with Judas.
Complete the Corpse with ???.
Complete the final chapter with ???.
Complete the final chapter with Eve.
Complete the Corpse with Samson.
Complete the final chapter with Samson.
Complete the final chapter with Azazel.
Complete the Corpse with Lazarus.
Complete the final chapter with Lazarus.
Complete the Corpse with Eden.
Complete the final chapter with Eden.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Complete the Corpse with Lilith.
Complete the Corpse with Keeper.
Complete the final chapter with Keeper.
Complete the Corpse with Apollyon.
Complete the final chapter with Apollyon.
Complete the Corpse with the Forgotten.
Complete the final chapter with the Forgotten.
Complete the Corpse with Bethany.
Complete the final chapter with Bethany.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
They will charge you up... for a small fee.
Beat everything in Hard Mode as every character.