Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
OMG!
111% now stop playing!
Unlocked a new co-player baby.
Unlocked a new character.
Beat caves without taking damage.
Built him out of meat cubes.
New mode unlocked!
Unlocked even more bosses!
Alt stage to the womb.
New boss in the womb!
Unlocked new bosses!
Beat womb without taking damage.
Beat depths without taking damage.
Beat Chest or Dark Room without taking damage.
You are the best!!
Donated 600 pennies to the shop.
Alt stage to the depths.
Isaac now holds the D6!
Alt stage to the caves.
New boss in the caves!
Donated 200 pennies to the shop.
New boss in the basement!
Your future's past waits.
Alt stage to the basement.
New boss in the depths!
They are waiting.
Unlocked new enemies!
The game just got harder!
Unlocked a new boss!
Unlocked Challenge #6.
Unlocked Challenge #7.
Unlocked Challenge #9.
Unlocked Challenge #11.
Unlocked Challenge #19.
Donated 100 pennies to the shop.
Unlocked another miniboss!
Unlocked Challenge #8.
Beat basement without taking damage.
You became Lord of the Flies.
Unlocked Challenge #20.
Unlocked Challenge #10.
Unlocked Challenge #4.
Donated 20 pennies to the shop.
The horsemen are loose.
Chapter 4 - The Womb unlocked.
Unlocked Challenge #5.
Destroy 100 rocks.
Unlocked...
Unlocked a new starting item.
Unlocked a new item
Nerd x 1000000
Unlocked a hidden chapter.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked Challenge #21.
Unlocked super special rocks.
Unlocked a new area.
Unlocked a new challenge.
Unlocked the power of RERUN.
They will charge you up... for a small fee.
Beat everything in Hard Mode as every character.
Complete the final chapter with Keeper.
Complete the final chapter with the Forgotten.
Complete the Corpse with the Forgotten.
Complete the Corpse with Keeper.
Beat everything in Hard mode with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete the Void with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Corpse with Apollyon.
Complete the Corpse with Eve.
Complete the Corpse with ???.
Complete the Corpse with the Lost.
Beat Greedier mode with Bethany.
Beat everything in Hard mode with Bethany.
Complete Boss Rush with Bethany.
Complete the Corpse with Lazarus.
Complete the Corpse with Cain.
Complete the Corpse with Bethany.
Complete the Corpse with Eden.
Complete the Corpse with Lilith.
Complete the final chapter with Lazarus.
Complete the Corpse with Judas.
Complete the final chapter with Cain.
Complete the final chapter with Judas.
Complete the final chapter with ???.
Get that song out of her head.
Complete the Chest with Bethany.
Complete ??? with Bethany.
Complete the Corpse with Samson.
Complete the final chapter with the Lost.
Complete the final chapter with Eve.
Complete the final chapter with Apollyon.
Complete the final chapter with Bethany.
Complete Boss Rush with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the final chapter with Samson.
Complete the Corpse with Isaac.
Complete the final chapter with Isaac.
Beat the Void with Bethany.
Complete the Dark Room with Bethany.
Defeat Mega Satan with Bethany.
Complete Sheol with Bethany.
Complete the final chapter with Lilith.
Complete the final chapter with Eden.
Complete the Corpse with Magdalene.
Complete the final chapter with Magdalene.
Defeat all bosses in the Mausoleum.
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Complete the final chapter with Azazel.
The other side is calling...
You are just like your father...
Enter the Corpse...
Defeat all bosses in Downpour.
Complete the Corpse with Azazel.
Where could it lead to?
Complete ??? 3 times.
Kill 10 Battery Bums.
Obtain 99 pennies. Then spend every single one of them.
Make a new friend!
Kids shouldn't believe in fortunes...
Complete the Cathedral with Bethany.
Defeat Baby Plum 10 times.
Beat Greed mode with Bethany.
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Spend 40+ pennies in a single shop.