Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new co-player baby.
Unlocked even more bosses!
Unlocked a new character.
New mode unlocked!
Beat Chest or Dark Room without taking damage.
Unlocked Challenge #19.
Isaac now holds the D6!
Donated 600 pennies to the shop.
Unlocked new enemies!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
You are the best!!
New boss in the womb!
They are waiting.
Beat depths without taking damage.
Beat womb without taking damage.
Beat caves without taking damage.
Donated 200 pennies to the shop.
Donated 100 pennies to the shop.
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked a new boss!
Unlocked Challenge #9.
Unlocked Challenge #8.
Unlocked another miniboss!
The game just got harder!
Built him out of meat cubes.
New boss in the depths!
New boss in the caves!
You became Lord of the Flies.
Unlocked Challenge #6.
New boss in the basement!
Unlocked Challenge #5.
Unlocked Challenge #10.
Beat basement without taking damage.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Donated 20 pennies to the shop.
Destroy 100 rocks.
OMG!
111% now stop playing!
Unlocked Challenge #11.
Unlocked a new starting item.
Nerd x 1000000
Unlocked a new item
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #24.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked Challenge #21.
Unlocked...
Unlocked a new challenge.
Unlocked super special rocks.
Unlocked a new area.
Unlocked the power of RERUN.
Complete the final chapter with Isaac.
Complete the final chapter with Bethany.
Beat the game in Hard mode with Bethany.
Kill 10 Battery Bums.
Defeat all bosses in the Mines.
Complete the final chapter with Apollyon.
Beat the Void with Bethany.
Complete the final chapter with Samson.
Complete the Corpse with Isaac.
Complete the final chapter with Lazarus.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat Greed mode with Bethany.
They will charge you up... for a small fee.
Complete Boss Rush with Bethany.
Complete the final chapter with ???.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete ??? with Bethany.
Beat Hard mode as Lazarus without losing a life
Complete the final chapter with Judas.
The other side is calling...
You are just like your father...
Where could it lead to?
Complete the Corpse with Cain.
Kids shouldn't believe in fortunes...
Defeat all bosses in the Mausoleum.
Kill Hornfel before he escapes!
Enter the Corpse...
Defeat all bosses in Downpour.
Complete ??? 3 times.
Obtain 99 pennies. Then spend every single one of them.
Defeat Baby Plum 10 times.
Spend 40+ pennies in a single shop.
Get that song out of her head.
Make a new friend!
Beat Greedier mode with Bethany.
Beat everything in Hard mode with Bethany.
Defeat Mega Satan with Bethany.
Beat the game in Hard mode with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with Magdalene.
Complete the final chapter with Magdalene.
Complete the final chapter with Cain.
Complete the Corpse with Judas.
Complete the Corpse with ???.
Complete the Corpse with Eve.
Complete the final chapter with Eve.
Complete the Corpse with Samson.
Complete the Corpse with Azazel.
Complete the final chapter with Azazel.
Complete the Corpse with Lazarus.
Complete the Corpse with Eden.
Complete the final chapter with Eden.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Complete the Corpse with Lilith.
Complete the final chapter with Lilith.
Complete the Corpse with Keeper.
Complete the final chapter with Keeper.
Complete the Corpse with Apollyon.
Complete the Corpse with the Forgotten.
Complete the final chapter with the Forgotten.
Complete the Corpse with Bethany.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Beat everything in Hard Mode as every character.