Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Donated 600 pennies to the shop.
Unlocked even more bosses!
Beat caves without taking damage.
Unlocked a new character.
Built him out of meat cubes.
Beat Chest or Dark Room without taking damage.
New mode unlocked!
New boss in the womb!
Alt stage to the womb.
Unlocked new bosses!
You are the best!!
Unlocked Challenge #11.
Unlocked a new co-player baby.
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Unlocked new enemies!
Isaac now holds the D6!
New boss in the caves!
They are waiting.
Unlocked Challenge #19.
Unlocked a new boss!
New boss in the basement!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked Challenge #8.
New boss in the depths!
Unlocked Challenge #9.
Unlocked another miniboss!
You became Lord of the Flies.
Beat basement without taking damage.
Donated 200 pennies to the shop.
The game just got harder!
Unlocked Challenge #6.
Donated 100 pennies to the shop.
Beat womb without taking damage.
Beat depths without taking damage.
Unlocked Challenge #5.
Unlocked Challenge #10.
Destroy 100 rocks.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Donated 20 pennies to the shop.
OMG!
111% now stop playing!
Nerd x 1000000
Unlocked a new starting item.
Unlocked Challenge #24.
Unlocked a secret.
Unlocked Challenge #27.
Unlocked Challenge #26.
Greed just got harder!
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked a new item
Unlocked...
Unlocked super special rocks.
Unlocked a new area.
Unlocked a new challenge.
Unlocked the power of RERUN.
Complete the Corpse with Judas.
Complete the final chapter with Judas.
Complete the Corpse with Magdalene.
Complete the final chapter with Magdalene.
Complete Boss Rush with Jacob and Esau.
Complete the Void with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the final chapter with Samson.
Complete the final chapter with Isaac.
Complete the final chapter with the Lost.
Complete the Corpse with Cain.
Complete the Corpse with Keeper.
Complete the Corpse with Bethany.
Complete the Corpse with Azazel.
Get that song out of her head.
Complete the final chapter with Lilith.
Complete the Dark Room with Bethany.
Beat the game in Hard mode with Bethany.
Complete Sheol with Bethany.
Complete the final chapter with Cain.
Defeat all bosses in the Mines.
Complete the Corpse with Isaac.
The other side is calling...
Kids shouldn't believe in fortunes...
Beat Greed mode with Jacob and Esau.
You are just like your father...
Complete the Corpse with the Forgotten.
Where could it lead to?
Kill Hornfel before he escapes!
Enter the Corpse...
Defeat all bosses in the Mausoleum.
Defeat all bosses in Downpour.
Complete ??? 3 times.
Kill 10 Battery Bums.
Beat Greed mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Obtain 99 pennies. Then spend every single one of them.
Defeat Baby Plum 10 times.
Spend 40+ pennies in a single shop.
Make a new friend!
Complete the Cathedral with Bethany.
Complete the Chest with Bethany.
Complete Boss Rush with Bethany.
Complete ??? with Bethany.
Beat Greedier mode with Bethany.
Beat the Void with Bethany.
Beat everything in Hard mode with Bethany.
Defeat Mega Satan with Bethany.
Complete Sheol with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with ???.
Complete the final chapter with ???.
Complete the Corpse with Eve.
Complete the final chapter with Eve.
Complete the Corpse with Samson.
Complete the final chapter with Azazel.
Complete the Corpse with Lazarus.
Complete the final chapter with Lazarus.
Complete the Corpse with Eden.
Complete the final chapter with Eden.
Complete the Corpse with the Lost.
Complete the Corpse with Lilith.
Complete the final chapter with Keeper.
Complete the Corpse with Apollyon.
Complete the final chapter with Apollyon.
Complete the final chapter with the Forgotten.
Complete the final chapter with Bethany.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
They will charge you up... for a small fee.
Beat everything in Hard Mode as every character.