Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
Chapter 4 - The Womb unlocked.
The horsemen are loose.
New boss in the basement!
New boss in the caves!
New boss in the depths!
Isaac now holds the D6!
The game just got harder!
Your future's past waits.
Beat basement without taking damage.
Beat caves without taking damage.
Beat depths without taking damage.
Beat womb without taking damage.
You are the best!!
Unlocked a new boss!
New boss in the womb!
OMG!
Beat Chest or Dark Room without taking damage.
111% now stop playing!
Destroy 100 rocks.
Unlocked another miniboss!
Built him out of meat cubes.
Donated 20 pennies to the shop.
Donated 100 pennies to the shop.
Donated 200 pennies to the shop.
Donated 600 pennies to the shop.
They are waiting.
Unlocked Challenge #4.
Unlocked Challenge #5.
Unlocked Challenge #6.
Unlocked Challenge #7.
Unlocked Challenge #8.
Unlocked Challenge #9.
Unlocked Challenge #10.
Unlocked Challenge #11.
Unlocked Challenge #19.
Unlocked Challenge #20.
Unlocked a new co-player baby.
You became Lord of the Flies.
Unlocked a new item
Unlocked a hidden chapter.
Unlocked a new starting item.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked a secret.
Greed just got harder!
Unlocked...
Nerd x 1000000
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
Complete the final chapter with the Lost.
Complete the Dark Room with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Obtain 99 pennies. Then spend every single one of them.
Complete the final chapter with Jacob and Esau.
Make a new friend!
Get that song out of her head.
Beat everything in Hard mode with Bethany.
Complete the final chapter with Bethany.
Complete the final chapter with Lilith.
Complete the final chapter with Eden.
Complete the final chapter with the Forgotten.
Kids shouldn't believe in fortunes...
Complete the final chapter with Apollyon.
Complete the Corpse with the Lost.
Complete the Corpse with Bethany.
Complete the final chapter with Lazarus.
They will charge you up... for a small fee.
Complete the Corpse with Keeper.
Complete the final chapter with Samson.
Complete the final chapter with Eve.
Complete the final chapter with Judas.
Complete the Corpse with the Forgotten.
Complete the final chapter with Cain.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the Corpse with Apollyon.
Complete the final chapter with Keeper.
Complete the Corpse with Lilith.
Complete the Corpse with Eden.
Complete the Corpse with Lazarus.
Complete the Corpse with Azazel.
Complete the final chapter with Azazel.
Complete the final chapter with Magdalene.
Complete the final chapter with Isaac.
Complete the Corpse with Samson.
Complete the Corpse with Eve.
Complete the Corpse with ???.
Kill 10 Battery Bums.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Spend 40+ pennies in a single shop.
Complete Boss Rush with Bethany.
Complete the final chapter with ???.
Complete the Corpse with Judas.
Complete the Corpse with Cain.
Complete the Corpse with Magdalene.
Defeat Baby Plum 10 times.
Defeat all bosses in the Mausoleum.
The other side is calling...
You are just like your father...
Complete the Corpse with Isaac.
Where could it lead to?
Enter the Corpse...
Beat the Void with Bethany.
Defeat Mega Satan with Bethany.
Complete the Dark Room with Bethany.
Complete ??? with Bethany.
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Complete Sheol with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Defeat all bosses in Downpour.
Complete ??? 3 times.
Beat Greed mode with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Beat everything in Hard Mode as every character.