Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new co-player baby.
Beat Chest or Dark Room without taking damage.
Unlocked even more bosses!
Beat womb without taking damage.
Unlocked a new character.
Unlocked Challenge #11.
You are the best!!
Unlocked new enemies!
New boss in the womb!
Unlocked new bosses!
Built him out of meat cubes.
New mode unlocked!
Alt stage to the womb.
Beat depths without taking damage.
Alt stage to the depths.
They are waiting.
Isaac now holds the D6!
Beat caves without taking damage.
Unlocked Challenge #8.
Donated 600 pennies to the shop.
Alt stage to the caves.
New boss in the caves!
Unlocked Challenge #19.
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Alt stage to the basement.
New boss in the depths!
Unlocked a new boss!
Unlocked Challenge #9.
New boss in the basement!
Unlocked another miniboss!
Donated 200 pennies to the shop.
The game just got harder!
Unlocked Challenge #6.
You became Lord of the Flies.
Beat basement without taking damage.
Unlocked Challenge #5.
Unlocked Challenge #10.
Donated 100 pennies to the shop.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Destroy 100 rocks.
Donated 20 pennies to the shop.
OMG!
111% now stop playing!
Unlocked...
Unlocked a new starting item.
Unlocked a new item
Nerd x 1000000
Unlocked Challenge #26.
Unlocked Challenge #24.
Unlocked a secret.
Unlocked Challenge #27.
Greed just got harder!
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked the power of RERUN.
Unlocked super special rocks.
Unlocked a new challenge.
Unlocked a new area.
Complete the Corpse with the Forgotten.
Complete the final chapter with the Forgotten.
Complete the Corpse with Bethany.
Beat Greedier mode with Bethany.
Complete the final chapter with Apollyon.
Beat everything in Hard mode with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Beat the Void with Bethany.
Complete the final chapter with Keeper.
Complete the Corpse with Lazarus.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete the final chapter with Eden.
Complete the Corpse with Eden.
Complete the Corpse with Keeper.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete ??? with Bethany.
Complete the final chapter with Azazel.
Complete the Corpse with Lilith.
Complete the Corpse with Apollyon.
Complete the final chapter with Samson.
Complete the Corpse with Samson.
Complete the final chapter with Eve.
Complete the Corpse with Eve.
Complete the final chapter with ???.
Complete the Void with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the Corpse with ???.
Complete the final chapter with the Lost.
Complete the Corpse with the Lost.
Complete the final chapter with Cain.
Complete the Corpse with Magdalene.
Complete the final chapter with Magdalene.
Kill 10 Battery Bums.
Complete the final chapter with Isaac.
Complete the Corpse with Isaac.
Complete the Corpse with Judas.
Complete the Corpse with Cain.
Beat Greed mode with Jacob and Esau.
Complete the final chapter with Lilith.
Kids shouldn't believe in fortunes...
Complete the final chapter with Lazarus.
Complete the final chapter with Judas.
Complete the final chapter with Bethany.
The other side is calling...
Obtain 99 pennies. Then spend every single one of them.
You are just like your father...
Complete the Corpse with Azazel.
Where could it lead to?
Enter the Corpse...
Get that song out of her head.
Defeat all bosses in the Mausoleum.
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Defeat all bosses in Downpour.
Complete ??? 3 times.
Complete Boss Rush with Bethany.
Defeat Baby Plum 10 times.
Beat Greed mode with Bethany.
Spend 40+ pennies in a single shop.
Make a new friend!
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Beat everything in Hard mode with Bethany.
They will charge you up... for a small fee.
Beat everything in Hard Mode as every character.