Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 4 DLC packs containing 395 achievements.
Unlocked a new item.
111% now stop playing!
OMG!
Unlocked a new co-player baby.
Donated 600 pennies to the shop.
Unlocked Challenge #11.
New mode unlocked!
Unlocked a new character.
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
You are the best!!
Built him out of meat cubes.
Unlocked Challenge #19.
Unlocked a new boss!
New boss in the womb!
Beat womb without taking damage.
New boss in the basement!
Beat Chest or Dark Room without taking damage.
New boss in the caves!
They are waiting.
You became Lord of the Flies.
New boss in the depths!
Beat depths without taking damage.
Donated 200 pennies to the shop.
Isaac now holds the D6!
Unlocked Challenge #4.
Unlocked Challenge #7.
Your future's past waits.
Unlocked Challenge #9.
Unlocked another miniboss!
The game just got harder!
Donated 100 pennies to the shop.
Beat caves without taking damage.
Unlocked Challenge #8.
Unlocked Challenge #6.
Beat basement without taking damage.
Unlocked Challenge #5.
Unlocked Challenge #10.
Destroy 100 rocks.
Donated 20 pennies to the shop.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Unlocked...
Unlocked a new item
Unlocked a new starting item.
Nerd x 1000000
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #24.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
They will charge you up... for a small fee.
Complete the Corpse with the Forgotten.
Beat everything in Hard Mode as every character.
Complete the Corpse with Keeper.
Complete the Corpse with Lilith.
Complete the Corpse with the Lost.
Complete the Corpse with Eden.
Complete the Corpse with Apollyon.
Complete the Corpse with Lazarus.
Complete the final chapter with the Lost.
Complete the final chapter with Keeper.
Complete the Corpse with Samson.
Complete the Corpse with Eve.
Complete the Corpse with ???.
Complete the final chapter with Eden.
Complete the Corpse with Azazel.
Complete the final chapter with Apollyon.
Complete the final chapter with Azazel.
Complete the Corpse with Judas.
Complete the final chapter with Samson.
Complete the final chapter with Eve.
Complete the final chapter with ???.
Complete the final chapter with the Forgotten.
Beat everything in Hard mode with Bethany.
Complete the final chapter with Bethany.
Kill 10 Battery Bums.
Complete the final chapter with Lazarus.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with Magdalene.
Complete the final chapter with Cain.
Complete the final chapter with Judas.
Complete the Corpse with Cain.
Complete the Corpse with Magdalene.
Make a new friend!
Get that song out of her head.
Kids shouldn't believe in fortunes...
Beat Greedier mode with Bethany.
Beat Greed mode with Bethany.
Complete the final chapter with Lilith.
Defeat Baby Plum 10 times.
Complete the final chapter with Isaac.
The other side is calling...
Obtain 99 pennies. Then spend every single one of them.
Complete the Corpse with Isaac.
You are just like your father...
Where could it lead to?
Complete the Corpse with Bethany.
Spend 40+ pennies in a single shop.
Enter the Corpse...
Defeat all bosses in the Mausoleum.
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Beat the Void with Bethany.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Defeat all bosses in Downpour.
Complete ??? 3 times.