Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Donated 600 pennies to the shop.
New mode unlocked!
Unlocked a new character.
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
Unlocked a new co-player baby.
Built him out of meat cubes.
Beat Chest or Dark Room without taking damage.
New boss in the womb!
You are the best!!
They are waiting.
Unlocked Challenge #11.
New boss in the caves!
Isaac now holds the D6!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked Challenge #19.
New boss in the basement!
Unlocked Challenge #9.
New boss in the depths!
Unlocked a new boss!
The game just got harder!
Beat womb without taking damage.
Unlocked another miniboss!
Beat depths without taking damage.
Unlocked Challenge #8.
Donated 200 pennies to the shop.
Beat caves without taking damage.
Beat basement without taking damage.
Donated 100 pennies to the shop.
Donated 20 pennies to the shop.
Unlocked Challenge #6.
You became Lord of the Flies.
Destroy 100 rocks.
Unlocked Challenge #5.
Unlocked Challenge #10.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
OMG!
111% now stop playing!
Unlocked a new starting item.
Unlocked a secret.
Nerd x 1000000
Greed just got harder!
Unlocked Challenge #24.
Unlocked a new item
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked...
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
Unlocked super special rocks.
Complete the final chapter with Apollyon.
Complete the Corpse with Apollyon.
Complete the Corpse with Judas.
Complete the final chapter with the Forgotten.
Complete the Corpse with the Forgotten.
Beat the game in Hard mode with Jacob and Esau.
Complete the final chapter with Judas.
Complete the final chapter with Cain.
Complete the Corpse with Cain.
Complete the Corpse with Magdalene.
Complete the final chapter with Magdalene.
Complete the Corpse with Eve.
Complete the final chapter with Eve.
Complete the final chapter with Lilith.
Complete the Corpse with Lilith.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Beat everything in Hard mode with Bethany.
Complete the Corpse with ???.
Complete the final chapter with ???.
Complete the Corpse with Samson.
Kill 10 Battery Bums.
Complete the final chapter with Samson.
Complete the Corpse with Lazarus.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Complete the final chapter with Bethany.
Complete the Corpse with Bethany.
Beat the Void with Bethany.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Complete the Corpse with Eden.
They will charge you up... for a small fee.
Complete the final chapter with the Lost.
Complete the Corpse with the Lost.
Beat Hard mode as Lazarus without losing a life
Complete the final chapter with Lazarus.
Kids shouldn't believe in fortunes...
Complete the final chapter with Eden.
Complete the Corpse with Azazel.
Complete the final chapter with Azazel.
Defeat Baby Plum 10 times.
Complete the final chapter with Isaac.
The other side is calling...
You are just like your father...
Complete the Corpse with Isaac.
Where could it lead to?
Enter the Corpse...
Obtain 99 pennies. Then spend every single one of them.
Spend 40+ pennies in a single shop.
Defeat all bosses in the Mines.
Defeat all bosses in Downpour.
Defeat all bosses in the Mausoleum.
Kill Hornfel before he escapes!
Get that song out of her head.
Complete ??? 3 times.
Make a new friend!
Complete the Cathedral with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with Keeper.
Complete the final chapter with Keeper.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
Beat everything in Hard Mode as every character.