Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
111% now stop playing!
Unlocked a new item.
OMG!
Unlocked a new co-player baby.
Unlocked Challenge #11.
Unlocked even more bosses!
Unlocked a new character.
New mode unlocked!
Unlocked new bosses!
Beat Chest or Dark Room without taking damage.
Isaac now holds the D6!
Beat womb without taking damage.
Beat depths without taking damage.
Beat caves without taking damage.
You are the best!!
New boss in the womb!
Unlocked Challenge #19.
They are waiting.
Unlocked new enemies!
Alt stage to the womb.
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Built him out of meat cubes.
You became Lord of the Flies.
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked Challenge #9.
Unlocked a new boss!
Unlocked Challenge #8.
Donated 600 pennies to the shop.
New boss in the depths!
The game just got harder!
Unlocked Challenge #6.
New boss in the caves!
Donated 200 pennies to the shop.
Donated 100 pennies to the shop.
Beat basement without taking damage.
Donated 20 pennies to the shop.
Unlocked another miniboss!
New boss in the basement!
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Unlocked Challenge #5.
Unlocked Challenge #10.
Destroy 100 rocks.
Unlocked...
Unlocked a new starting item.
Nerd x 1000000
Unlocked a new item
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #24.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
Beat everything in Hard mode with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the final chapter with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the Corpse with Apollyon.
Complete the final chapter with Apollyon.
Complete the Corpse with Lilith.
Complete the final chapter with Eve.
Complete the Corpse with ???.
Complete the Corpse with Eden.
Complete the Corpse with Lazarus.
Beat everything in Hard mode with Bethany.
Complete the final chapter with Keeper.
Complete the final chapter with Magdalene.
Complete the Corpse with Magdalene.
Complete the final chapter with Lazarus.
Complete the Corpse with Eve.
Complete the final chapter with Judas.
Complete the Corpse with Judas.
Complete the final chapter with Samson.
Complete the Corpse with Isaac.
Complete the Corpse with the Forgotten.
Complete the Corpse with Cain.
Complete the final chapter with the Forgotten.
Complete the final chapter with Bethany.
Defeat Mega Satan with Bethany.
Beat the game in Hard mode with Bethany.
Complete the Corpse with Azazel.
Complete the final chapter with Isaac.
Complete the final chapter with Azazel.
Beat Greedier mode with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Complete Boss Rush with Jacob and Esau.
Complete the final chapter with the Lost.
Complete the Corpse with the Lost.
Complete the Corpse with Keeper.
Complete ??? with Jacob and Esau.
Beat the Void with Bethany.
Kill 10 Battery Bums.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
They will charge you up... for a small fee.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete the Corpse with Bethany.
Complete the Dark Room with Bethany.
Complete ??? with Bethany.
Complete Boss Rush with Bethany.
Complete the final chapter with ???.
Complete the Void with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete the final chapter with Eden.
Complete Sheol with Jacob and Esau.
Make a new friend!
Obtain 99 pennies. Then spend every single one of them.
Complete the final chapter with Lilith.
Kids shouldn't believe in fortunes...
Complete the final chapter with Cain.
Spend 40+ pennies in a single shop.
The other side is calling...
You are just like your father...
Where could it lead to?
Complete the Corpse with Samson.
Complete Sheol with Bethany.
Beat Hard mode as Lazarus without losing a life
Defeat Baby Plum 10 times.
Defeat all bosses in the Mausoleum.
Enter the Corpse...
Defeat all bosses in the Mines.
Kill Hornfel before he escapes!
Defeat all bosses in Downpour.
Get that song out of her head.
Complete ??? 3 times.