Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
New mode unlocked!
Beat caves without taking damage.
Unlocked a new character.
New boss in the womb!
Unlocked new bosses!
Unlocked Challenge #19.
You are the best!!
Beat Chest or Dark Room without taking damage.
Unlocked a new co-player baby.
They are waiting.
Unlocked new enemies!
Beat womb without taking damage.
Alt stage to the womb.
Isaac now holds the D6!
Alt stage to the depths.
Donated 600 pennies to the shop.
Alt stage to the basement.
Alt stage to the caves.
Beat depths without taking damage.
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Donated 200 pennies to the shop.
Built him out of meat cubes.
Donated 100 pennies to the shop.
Unlocked Challenge #9.
Unlocked Challenge #8.
You became Lord of the Flies.
New boss in the depths!
Unlocked a new boss!
Unlocked another miniboss!
The game just got harder!
New boss in the caves!
Unlocked Challenge #6.
New boss in the basement!
Beat basement without taking damage.
Donated 20 pennies to the shop.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Destroy 100 rocks.
Unlocked Challenge #5.
Unlocked Challenge #10.
OMG!
111% now stop playing!
Unlocked Challenge #11.
Unlocked even more bosses!
Nerd x 1000000
Unlocked a new starting item.
Unlocked Challenge #24.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked a secret.
Greed just got harder!
Unlocked Challenge #23.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #25.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked a new item
Unlocked...
Unlocked super special rocks.
Unlocked a new challenge.
Unlocked a new area.
Unlocked the power of RERUN.
Complete the final chapter with Isaac.
Get that song out of her head.
Make a new friend!
Obtain 99 pennies. Then spend every single one of them.
The other side is calling...
You are just like your father...
Complete the Corpse with Azazel.
Where could it lead to?
Spend 40+ pennies in a single shop.
Beat Greed mode with Bethany.
Kill Hornfel before he escapes!
Defeat all bosses in the Mausoleum.
Enter the Corpse...
Defeat Baby Plum 10 times.
Complete ??? with Bethany.
Beat the game in Hard mode with Bethany.
Complete Boss Rush with Bethany.
Beat Hard mode as Lazarus without losing a life
Defeat all bosses in the Mines.
Defeat all bosses in Downpour.
Kids shouldn't believe in fortunes...
Complete ??? 3 times.
Complete the Cathedral with Bethany.
Complete Sheol with Bethany.
Complete the Chest with Bethany.
Complete the Dark Room with Bethany.
Beat Greedier mode with Bethany.
Beat the Void with Bethany.
Beat everything in Hard mode with Bethany.
Defeat Mega Satan with Bethany.
Beat the game in Hard mode with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with Isaac.
Complete the Corpse with Magdalene.
Complete the final chapter with Magdalene.
Complete the Corpse with Cain.
Complete the final chapter with Cain.
Complete the Corpse with Judas.
Complete the final chapter with Judas.
Complete the Corpse with ???.
Complete the final chapter with ???.
Complete the Corpse with Eve.
Complete the final chapter with Eve.
Complete the Corpse with Samson.
Complete the final chapter with Samson.
Complete the final chapter with Azazel.
Complete the Corpse with Lazarus.
Complete the final chapter with Lazarus.
Complete the Corpse with Eden.
Complete the final chapter with Eden.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Complete the Corpse with Lilith.
Complete the final chapter with Lilith.
Complete the Corpse with Keeper.
Complete the final chapter with Keeper.
Complete the Corpse with Apollyon.
Complete the final chapter with Apollyon.
Complete the Corpse with the Forgotten.
Complete the final chapter with the Forgotten.
Complete the Corpse with Bethany.
Complete the final chapter with Bethany.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Jacob and Esau.
They will charge you up... for a small fee.
Kill 10 Battery Bums.
Beat everything in Hard Mode as every character.