Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
111% now stop playing!
OMG!
Unlocked a new co-player baby.
Beat Chest or Dark Room without taking damage.
Unlocked Challenge #11.
Unlocked Challenge #19.
Donated 600 pennies to the shop.
You became Lord of the Flies.
New boss in the womb!
You are the best!!
Unlocked a new boss!
Built him out of meat cubes.
Beat womb without taking damage.
New boss in the caves!
New boss in the depths!
Isaac now holds the D6!
New boss in the basement!
They are waiting.
Unlocked Challenge #4.
Unlocked Challenge #7.
Your future's past waits.
Unlocked Challenge #9.
Beat depths without taking damage.
Unlocked Challenge #8.
The game just got harder!
Donated 200 pennies to the shop.
Unlocked Challenge #6.
Unlocked another miniboss!
Beat caves without taking damage.
Donated 100 pennies to the shop.
Unlocked Challenge #5.
Unlocked Challenge #10.
Destroy 100 rocks.
Beat basement without taking damage.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Donated 20 pennies to the shop.
Nerd x 1000000
Unlocked...
Unlocked a new starting item.
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked a new item
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
Kill 10 Battery Bums.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Beat everything in Hard Mode as every character.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Void with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat Greedier mode with Bethany.
Beat everything in Hard mode with Bethany.
Beat Greed mode with Bethany.
Complete the Dark Room with Bethany.
Complete ??? with Bethany.
Beat the Void with Bethany.
Complete Sheol with Bethany.
Complete the final chapter with Keeper.
Complete the final chapter with Apollyon.
Complete the Corpse with Keeper.
Complete the Corpse with Apollyon.
Complete the final chapter with Lilith.
Complete the Corpse with Lilith.
Complete the Corpse with Lazarus.
Complete the Corpse with the Lost.
Complete the final chapter with the Lost.
Complete the final chapter with Lazarus.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete Boss Rush with Bethany.
Complete the Corpse with Jacob and Esau.
Complete the Corpse with Bethany.
Beat the game in Hard mode with Jacob and Esau.
Complete the final chapter with Samson.
Complete the final chapter with Bethany.
Kids shouldn't believe in fortunes...
Complete the Corpse with Eve.
Complete the Corpse with Samson.
Complete the final chapter with Cain.
Complete the final chapter with ???.
Complete the final chapter with Eve.
Complete the final chapter with Magdalene.
Complete the final chapter with Judas.
Complete the Corpse with Cain.
Complete the Corpse with Judas.
Complete the Corpse with Magdalene.
Complete the Corpse with ???.
Complete the Corpse with Azazel.
Spend 40+ pennies in a single shop.
Complete the final chapter with Azazel.
Complete the final chapter with the Forgotten.
Obtain 99 pennies. Then spend every single one of them.
Defeat Baby Plum 10 times.
Complete the final chapter with Isaac.
Complete the final chapter with Eden.
Complete the final chapter with Jacob and Esau.
The other side is calling...
Complete the Corpse with Isaac.
Defeat all bosses in the Mines.
You are just like your father...
Complete the Corpse with Eden.
Complete the Corpse with the Forgotten.
Where could it lead to?
Enter the Corpse...
Get that song out of her head.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Defeat all bosses in Downpour.
Defeat all bosses in the Mausoleum.
Kill Hornfel before he escapes!
Complete ??? 3 times.
Make a new friend!
They will charge you up... for a small fee.