Here is the full list of all 43 Prototype 2 achievements. It takes around 20-25 hours to unlock all of the achievements on Windows.
Complete the game on HARD difficulty.
Complete all //BLACKNET dossiers.
Fully upgrade Heller.
Destroy all Lairs.
Find all BlackBoxes.
Defeat all Field Ops teams.
Spend at least 25 consecutive seconds in the air (helicopters don't count).
Acquire all 46 upgrades through Consumes.
Acquire a Mutation in each of the 5 categories.
Simultaneously kill 2 Brawlers using a single Devastator.
Destroy 5 helicopters using Pack Leader.
Destroy a Strike Team in 15 seconds or less.
Complete the game.
Complete LABOR OF LOVE.
Travel a half mile using only Wall Run, Glide, Jump and Air Dash.
Acquire 30 upgrades through Consumes.
Destroy 10 Blackwatch tanks, APCs or helicopters using a single hijacked tank or APC.
10 or more kills using a single Bio-Bomb.
Mount a helicopter using Whipfist.
Reach the highest point in the world.
Consume 10 //BLACKNET targets.
Stealth hijack 5 tanks or APCs.
Complete FALL FROM GRACE.
20 or more kills with a single Hammerfist dive attack.
Weaponize 10 vehicles.
Destroy 5 vehicles using a Finisher.
Acquire 5 Mutations.
Destroy a single Lair.
Acquire 10 upgrades through Consumes.
Complete NATURAL SELECTION.
Counter enemy attacks 20 times using Shield.
Deflect 5 missiles at enemies using Shield Block.
Trigger 50 alerts.
10 or more kills with a single Black Hole attack.
Stealth Consume 50 Blackwatch troopers.
Karate kick a helicopter.
5 consumes in 10 seconds or less.
Complete a //BLACKNET operation.
Dismember a Brawler.
Acquire a Prototype Power.
Meet Father Guerra.
Complete RESURRECTION.
Complete MEET YOUR MAKER.