Here is the full list of all 43 Prototype 2 achievements. It takes around 20-25 hours to unlock all of the achievements on Windows.
Fully upgrade Heller.
Complete the game on HARD difficulty.
Complete the game.
Complete LABOR OF LOVE.
Acquire all 46 upgrades through Consumes.
Destroy a Strike Team in 15 seconds or less.
Weaponize 10 vehicles.
Destroy 5 helicopters using Pack Leader.
Destroy 10 Blackwatch tanks, APCs or helicopters using a single hijacked tank or APC.
Simultaneously kill 2 Brawlers using a single Devastator.
Travel a half mile using only Wall Run, Glide, Jump and Air Dash.
Spend at least 25 consecutive seconds in the air (helicopters don't count).
Reach the highest point in the world.
Mount a helicopter using Whipfist.
Destroy 5 vehicles using a Finisher.
10 or more kills with a single Black Hole attack.
Complete all //BLACKNET dossiers.
20 or more kills with a single Hammerfist dive attack.
10 or more kills using a single Bio-Bomb.
Acquire 30 upgrades through Consumes.
Destroy all Lairs.
Defeat all Field Ops teams.
Find all BlackBoxes.
Complete FALL FROM GRACE.
Stealth hijack 5 tanks or APCs.
Consume 10 //BLACKNET targets.
Acquire a Mutation in each of the 5 categories.
Destroy a single Lair.
Acquire 10 upgrades through Consumes.
Complete NATURAL SELECTION.
Karate kick a helicopter.
Counter enemy attacks 20 times using Shield.
Trigger 50 alerts.
Deflect 5 missiles at enemies using Shield Block.
Stealth Consume 50 Blackwatch troopers.
5 consumes in 10 seconds or less.
Acquire 5 Mutations.
Complete a //BLACKNET operation.
Dismember a Brawler.
Acquire a Prototype Power.
Meet Father Guerra.
Complete RESURRECTION.
Complete MEET YOUR MAKER.