Here is the full list of all 43 Prototype 2 achievements. It takes around 20-25 hours to unlock all of the achievements on Windows.
Fully upgrade Heller.
Acquire all 46 upgrades through Consumes.
Complete the game.
Complete the game on HARD difficulty.
Destroy 5 vehicles using a Finisher.
Destroy 5 helicopters using Pack Leader.
Mount a helicopter using Whipfist.
Complete LABOR OF LOVE.
Complete all //BLACKNET dossiers.
Simultaneously kill 2 Brawlers using a single Devastator.
Destroy 10 Blackwatch tanks, APCs or helicopters using a single hijacked tank or APC.
Stealth hijack 5 tanks or APCs.
Spend at least 25 consecutive seconds in the air (helicopters don't count).
Defeat all Field Ops teams.
Find all BlackBoxes.
Destroy all Lairs.
Acquire 30 upgrades through Consumes.
10 or more kills using a single Bio-Bomb.
Reach the highest point in the world.
Travel a half mile using only Wall Run, Glide, Jump and Air Dash.
Complete FALL FROM GRACE.
Destroy a Strike Team in 15 seconds or less.
Acquire a Mutation in each of the 5 categories.
Karate kick a helicopter.
Consume 10 //BLACKNET targets.
Stealth Consume 50 Blackwatch troopers.
20 or more kills with a single Hammerfist dive attack.
Acquire 10 upgrades through Consumes.
10 or more kills with a single Black Hole attack.
Destroy a single Lair.
Complete NATURAL SELECTION.
Counter enemy attacks 20 times using Shield.
Deflect 5 missiles at enemies using Shield Block.
Weaponize 10 vehicles.
Acquire 5 Mutations.
Trigger 50 alerts.
Complete a //BLACKNET operation.
Dismember a Brawler.
Acquire a Prototype Power.
5 consumes in 10 seconds or less.
Meet Father Guerra.
Complete RESURRECTION.
Complete MEET YOUR MAKER.