Here is the full list of all 43 Prototype 2 achievements. It takes around 20-25 hours to unlock all of the achievements on Windows.
Fully upgrade Heller.
Acquire all 46 upgrades through Consumes.
Spend at least 25 consecutive seconds in the air (helicopters don't count).
Complete the game on HARD difficulty.
Complete the game.
Complete LABOR OF LOVE.
Complete all //BLACKNET dossiers.
Mount a helicopter using Whipfist.
Destroy all Lairs.
Acquire 30 upgrades through Consumes.
Reach the highest point in the world.
Find all BlackBoxes.
Destroy 5 helicopters using Pack Leader.
Defeat all Field Ops teams.
Travel a half mile using only Wall Run, Glide, Jump and Air Dash.
Complete FALL FROM GRACE.
Simultaneously kill 2 Brawlers using a single Devastator.
Acquire a Mutation in each of the 5 categories.
Weaponize 10 vehicles.
20 or more kills with a single Hammerfist dive attack.
10 or more kills using a single Bio-Bomb.
Destroy 5 vehicles using a Finisher.
Consume 10 //BLACKNET targets.
Destroy 10 Blackwatch tanks, APCs or helicopters using a single hijacked tank or APC.
Stealth hijack 5 tanks or APCs.
Acquire 10 upgrades through Consumes.
Destroy a Strike Team in 15 seconds or less.
Destroy a single Lair.
Complete NATURAL SELECTION.
Karate kick a helicopter.
Counter enemy attacks 20 times using Shield.
Deflect 5 missiles at enemies using Shield Block.
Acquire 5 Mutations.
Trigger 50 alerts.
10 or more kills with a single Black Hole attack.
Stealth Consume 50 Blackwatch troopers.
Complete a //BLACKNET operation.
Dismember a Brawler.
Acquire a Prototype Power.
5 consumes in 10 seconds or less.
Meet Father Guerra.
Complete RESURRECTION.
Complete MEET YOUR MAKER.