Here is the full list of all 43 Prototype 2 achievements. It takes around 20-25 hours to unlock all of the achievements on Windows.
Complete the game.
Complete LABOR OF LOVE.
Complete all //BLACKNET dossiers.
Acquire 30 upgrades through Consumes.
10 or more kills using a single Bio-Bomb.
Complete FALL FROM GRACE.
Consume 10 //BLACKNET targets.
Acquire a Mutation in each of the 5 categories.
20 or more kills with a single Hammerfist dive attack.
Destroy a single Lair.
Stealth Consume 50 Blackwatch troopers.
Acquire 5 Mutations.
Acquire 10 upgrades through Consumes.
Complete NATURAL SELECTION.
Deflect 5 missiles at enemies using Shield Block.
Counter enemy attacks 20 times using Shield.
5 consumes in 10 seconds or less.
Trigger 50 alerts.
Complete a //BLACKNET operation.
Dismember a Brawler.
Acquire a Prototype Power.
Meet Father Guerra.
Complete RESURRECTION.
Complete MEET YOUR MAKER.
Find all BlackBoxes.
Defeat all Field Ops teams.
Destroy a Strike Team in 15 seconds or less.
10 or more kills with a single Black Hole attack.
Simultaneously kill 2 Brawlers using a single Devastator.
Stealth hijack 5 tanks or APCs.
Destroy 10 Blackwatch tanks, APCs or helicopters using a single hijacked tank or APC.
Travel a half mile using only Wall Run, Glide, Jump and Air Dash.
Destroy 5 helicopters using Pack Leader.
Weaponize 10 vehicles.
Karate kick a helicopter.
Mount a helicopter using Whipfist.
Destroy 5 vehicles using a Finisher.
Spend at least 25 consecutive seconds in the air (helicopters don't count).
Acquire all 46 upgrades through Consumes.
Reach the highest point in the world.
Destroy all Lairs.
Fully upgrade Heller.
Complete the game on HARD difficulty.