Here is the full list of all 43 Prototype 2 achievements. It takes around 20-25 hours to unlock all of the achievements on Windows.
Complete the game on HARD difficulty.
Fully upgrade Heller.
Acquire all 46 upgrades through Consumes.
Find all BlackBoxes.
Defeat all Field Ops teams.
Destroy all Lairs.
Complete the game.
Complete LABOR OF LOVE.
Spend at least 25 consecutive seconds in the air (helicopters don't count).
Complete all //BLACKNET dossiers.
Destroy 5 helicopters using Pack Leader.
10 or more kills with a single Black Hole attack.
Destroy a Strike Team in 15 seconds or less.
Stealth hijack 5 tanks or APCs.
10 or more kills using a single Bio-Bomb.
Simultaneously kill 2 Brawlers using a single Devastator.
Acquire 30 upgrades through Consumes.
Destroy 10 Blackwatch tanks, APCs or helicopters using a single hijacked tank or APC.
Mount a helicopter using Whipfist.
Destroy 5 vehicles using a Finisher.
Reach the highest point in the world.
Stealth Consume 50 Blackwatch troopers.
Complete FALL FROM GRACE.
Weaponize 10 vehicles.
20 or more kills with a single Hammerfist dive attack.
Acquire a Mutation in each of the 5 categories.
Consume 10 //BLACKNET targets.
Acquire 5 Mutations.
Destroy a single Lair.
Acquire 10 upgrades through Consumes.
Complete NATURAL SELECTION.
Karate kick a helicopter.
Counter enemy attacks 20 times using Shield.
Deflect 5 missiles at enemies using Shield Block.
Trigger 50 alerts.
Travel a half mile using only Wall Run, Glide, Jump and Air Dash.
Complete a //BLACKNET operation.
Dismember a Brawler.
5 consumes in 10 seconds or less.
Acquire a Prototype Power.
Meet Father Guerra.
Complete RESURRECTION.
Complete MEET YOUR MAKER.