Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new co-player baby.
Donated 600 pennies to the shop.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
Beat Chest or Dark Room without taking damage.
You became Lord of the Flies.
Unlocked Challenge #11.
Built him out of meat cubes.
Isaac now holds the D6!
Beat womb without taking damage.
New boss in the womb!
You are the best!!
Unlocked Challenge #19.
They are waiting.
New boss in the caves!
Donated 200 pennies to the shop.
Beat depths without taking damage.
Beat caves without taking damage.
New boss in the basement!
New boss in the depths!
Unlocked a new boss!
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
Unlocked Challenge #9.
Unlocked another miniboss!
Donated 100 pennies to the shop.
The game just got harder!
Unlocked Challenge #6.
Unlocked Challenge #5.
Unlocked Challenge #10.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Beat basement without taking damage.
Destroy 100 rocks.
Donated 20 pennies to the shop.
Unlocked Challenge #8.
Unlocked Challenge #20.
OMG!
111% now stop playing!
Unlocked...
Nerd x 1000000
Unlocked a new starting item.
Unlocked a secret.
Unlocked Challenge #24.
Greed just got harder!
Unlocked a new item
Unlocked Challenge #26.
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #25.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
Complete the Corpse with Apollyon.
Complete the Corpse with Samson.
You are just like your father...
Kids shouldn't believe in fortunes...
Beat the game in Hard mode with Bethany.
Complete Boss Rush with Bethany.
Complete the Corpse with Bethany.
Where could it lead to?
Beat the Void with Bethany.
They will charge you up... for a small fee.
Complete the Corpse with Eve.
Complete the Corpse with Judas.
Complete the Corpse with ???.
Beat Greedier mode with Bethany.
Beat Greedier mode with Jacob and Esau.
Complete the final chapter with Samson.
Complete the final chapter with Eve.
Complete the final chapter with Lilith.
Complete the final chapter with ???.
Complete the final chapter with Judas.
Complete the final chapter with the Forgotten.
Complete the final chapter with Cain.
Complete the Corpse with Cain.
Complete the Corpse with Lilith.
Complete the Corpse with Magdalene.
Complete the final chapter with Magdalene.
Complete the Corpse with Keeper.
Complete the final chapter with Keeper.
Complete the final chapter with Bethany.
Defeat Mega Satan with Bethany.
Complete ??? with Bethany.
Beat Greed mode with Jacob and Esau.
Complete the final chapter with the Lost.
Complete the Corpse with the Lost.
Complete the final chapter with Eden.
Obtain 99 pennies. Then spend every single one of them.
Complete the Corpse with Eden.
Complete the final chapter with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Complete the final chapter with Lazarus.
Complete the Corpse with Lazarus.
Complete the final chapter with Apollyon.
Complete the Corpse with Isaac.
Complete the final chapter with Isaac.
Complete the Corpse with the Forgotten.
Complete the Void with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete ??? with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Complete the Corpse with Azazel.
Complete the final chapter with Azazel.
The other side is calling...
Defeat Baby Plum 10 times.
Complete the Chest with Bethany.
Defeat all bosses in the Mausoleum.
Complete the Cathedral with Bethany.
Enter the Corpse...
Defeat all bosses in the Mines.
Beat Greed mode with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Get that song out of her head.
Make a new friend!
Beat Hard mode as Lazarus without losing a life
Defeat all bosses in Downpour.
Spend 40+ pennies in a single shop.
Kill Hornfel before he escapes!
Complete ??? 3 times.
Beat everything in Hard mode with Bethany.
Beat the game in Hard mode with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Kill 10 Battery Bums.
Beat everything in Hard Mode as every character.