Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
Unlocked a new character.
OMG!
111% now stop playing!
Unlocked Challenge #11.
Unlocked a new co-player baby.
You became Lord of the Flies.
Donated 600 pennies to the shop.
Built him out of meat cubes.
New boss in the womb!
You are the best!!
Beat Chest or Dark Room without taking damage.
Beat depths without taking damage.
Beat caves without taking damage.
Isaac now holds the D6!
Unlocked Challenge #19.
New boss in the basement!
New boss in the caves!
They are waiting.
Your future's past waits.
Unlocked Challenge #4.
Unlocked Challenge #7.
New boss in the depths!
Donated 200 pennies to the shop.
Unlocked a new boss!
Unlocked Challenge #9.
The game just got harder!
Beat womb without taking damage.
Donated 100 pennies to the shop.
Unlocked another miniboss!
Unlocked Challenge #6.
Unlocked Challenge #5.
Unlocked Challenge #10.
Beat basement without taking damage.
Donated 20 pennies to the shop.
Destroy 100 rocks.
Unlocked Challenge #8.
The horsemen are loose.
Unlocked Challenge #20.
Chapter 4 - The Womb unlocked.
Nerd x 1000000
Unlocked...
Unlocked a new starting item.
Unlocked a new item
Unlocked Challenge #24.
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked Challenge #21.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
They will charge you up... for a small fee.
Make a new friend!
Beat everything in Hard Mode as every character.
Complete the final chapter with the Forgotten.
Complete the final chapter with Apollyon.
Complete the Corpse with Apollyon.
Complete the final chapter with Keeper.
Complete the final chapter with Lilith.
Complete the Corpse with Lilith.
Complete the final chapter with the Lost.
Complete the Corpse with the Lost.
Complete the Corpse with the Forgotten.
Complete the final chapter with Lazarus.
Complete the Corpse with Lazarus.
Complete the final chapter with Azazel.
Complete the Corpse with Samson.
Complete the final chapter with Eve.
Complete the Corpse with Eve.
Complete the final chapter with ???.
Complete the Corpse with ???.
Complete the final chapter with Judas.
Complete the Corpse with Judas.
Complete the final chapter with Cain.
Complete the Corpse with Cain.
Complete the Corpse with Keeper.
Complete the Corpse with Magdalene.
Complete the final chapter with Magdalene.
Complete the final chapter with Eden.
Complete the final chapter with Isaac.
Complete the Corpse with Isaac.
Beat Greed mode with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Void with Jacob and Esau.
Complete ??? with Jacob and Esau.
Kill 10 Battery Bums.
Complete the final chapter with Jacob and Esau.
Complete the final chapter with Samson.
Complete the Chest with Jacob and Esau.
Complete the Cathedral with Jacob and Esau.
Complete Boss Rush with Jacob and Esau.
Beat everything in Hard mode with Bethany.
Complete the final chapter with Bethany.
Beat Greed mode with Bethany.
Beat Greedier mode with Bethany.
Beat the Void with Bethany.
Complete the Dark Room with Bethany.
Complete Sheol with Bethany.
Defeat Mega Satan with Bethany.
Complete the Chest with Bethany.
Complete the Cathedral with Bethany.
Complete Boss Rush with Bethany.
Complete the Corpse with Bethany.
Get that song out of her head.
Complete the Corpse with Eden.
Obtain 99 pennies. Then spend every single one of them.
The other side is calling...
Complete the Corpse with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Kids shouldn't believe in fortunes...
Defeat Baby Plum 10 times.
You are just like your father...
Where could it lead to?
Complete the Corpse with Azazel.
Kill Hornfel before he escapes!
Defeat all bosses in the Mausoleum.
Defeat all bosses in the Mines.
Enter the Corpse...
Complete ??? with Bethany.
Beat the game in Hard mode with Bethany.
Spend 40+ pennies in a single shop.
Beat Hard mode as Lazarus without losing a life
Defeat all bosses in Downpour.
Complete ??? 3 times.