Full list of all 637 The Binding of Isaac: Rebirth achievements. It takes around 200 hours to unlock all of the achievements in the base game on Windows.
The base game contains 242 achievements, and there are 3 DLC packs containing 395 achievements.
Unlocked a new item.
Unlocked a new character.
New mode unlocked!
Alt stage to the basement.
Alt stage to the caves.
Alt stage to the depths.
Alt stage to the womb.
Unlocked new bosses!
Unlocked even more bosses!
Unlocked new enemies!
OMG!
111% now stop playing!
Beat depths without taking damage.
Beat Chest or Dark Room without taking damage.
Beat womb without taking damage.
Unlocked a new co-player baby.
Built him out of meat cubes.
Donated 600 pennies to the shop.
Beat caves without taking damage.
New boss in the womb!
Unlocked Challenge #11.
You are the best!!
Unlocked Challenge #19.
They are waiting.
Isaac now holds the D6!
Unlocked a new boss!
Donated 200 pennies to the shop.
Unlocked Challenge #4.
Unlocked Challenge #7.
Your future's past waits.
New boss in the caves!
New boss in the depths!
Unlocked Challenge #9.
Unlocked Challenge #8.
The game just got harder!
Donated 100 pennies to the shop.
New boss in the basement!
Unlocked another miniboss!
Unlocked Challenge #6.
Beat basement without taking damage.
You became Lord of the Flies.
Donated 20 pennies to the shop.
Unlocked Challenge #5.
Unlocked Challenge #10.
Destroy 100 rocks.
Chapter 4 - The Womb unlocked.
The horsemen are loose.
Unlocked Challenge #20.
Nerd x 1000000
Unlocked...
Unlocked a new starting item.
Unlocked a new item
Unlocked a secret.
Greed just got harder!
Unlocked a hidden chapter.
Unlocked Challenge #21.
Unlocked Challenge #22.
Unlocked Challenge #23.
Unlocked Challenge #24.
Unlocked Challenge #25.
Unlocked Challenge #26.
Unlocked Challenge #27.
Unlocked Challenge #28.
Unlocked Challenge #29.
Unlocked Challenge #30.
Unlocked super special rocks.
Unlocked the power of RERUN.
Unlocked a new area.
Unlocked a new challenge.
Complete the Chest with Bethany.
They will charge you up... for a small fee.
Complete the final chapter with the Forgotten.
Complete the Corpse with the Forgotten.
Complete the Corpse with Apollyon.
Complete the Corpse with Lilith.
Complete the Corpse with Lazarus.
Complete the Corpse with Samson.
Complete the Corpse with Eve.
Beat the Void with Bethany.
Complete ??? with Bethany.
Complete the Dark Room with Jacob and Esau.
Complete Sheol with Jacob and Esau.
Complete the Chest with Jacob and Esau.
Complete the Corpse with Bethany.
Complete the Dark Room with Bethany.
Complete Boss Rush with Bethany.
Complete the final chapter with Keeper.
Complete the Corpse with Keeper.
Complete the final chapter with Apollyon.
Complete the Corpse with the Lost.
Complete the Corpse with Judas.
Complete the Corpse with Magdalene.
Complete the Corpse with Eden.
Complete the Corpse with Isaac.
Complete the Corpse with Azazel.
Complete the final chapter with Jacob and Esau.
Make a new friend!
Complete the final chapter with Judas.
Complete the Cathedral with Jacob and Esau.
Complete the final chapter with Samson.
Complete the final chapter with Isaac.
Complete the final chapter with Eden.
Complete the final chapter with Azazel.
Complete Boss Rush with Jacob and Esau.
Beat the game in Hard mode with Jacob and Esau.
Complete the final chapter with ???.
Complete the final chapter with Eve.
Complete the Corpse with ???.
Beat Greed mode with Bethany.
Obtain 99 pennies. Then spend every single one of them.
Complete the final chapter with Lilith.
Complete the final chapter with the Lost.
Complete the final chapter with Magdalene.
Defeat Mega Satan with Bethany.
Complete Sheol with Bethany.
Complete the final chapter with Lazarus.
Complete the final chapter with Cain.
Defeat all bosses in the Mines.
Defeat all bosses in the Mausoleum.
Complete the final chapter with Bethany.
Kill 10 Battery Bums.
The other side is calling...
Kids shouldn't believe in fortunes...
You are just like your father...
Complete the Corpse with Cain.
Where could it lead to?
Enter the Corpse...
Kill Hornfel before he escapes!
Defeat all bosses in Downpour.
Get that song out of her head.
Complete the Cathedral with Bethany.
Spend 40+ pennies in a single shop.
Defeat Baby Plum 10 times.
Beat the game in Hard mode with Bethany.
Beat Hard mode as Lazarus without losing a life
Complete ??? 3 times.
Beat Greedier mode with Bethany.
Beat everything in Hard mode with Bethany.
Beat Greed mode with Jacob and Esau.
Complete ??? with Jacob and Esau.
Beat Greedier mode with Jacob and Esau.
Complete the Void with Jacob and Esau.
Beat everything in Hard mode with Jacob and Esau.
Defeat Mega Satan with Jacob and Esau.
Complete the Corpse with Jacob and Esau.
Beat everything in Hard Mode as every character.